Apolipoprotein E and alpha(1)-antichymotrypsin polymorphism in Alzheimer's disease

被引：36
作者：
Nacmias, B
Tedde, A
Latorraca, S
Piacentini, S
Bracco, L
Amaducci, L
Guarnieri, BM
Petruzzi, C
Ortenzi, L
Sorbi, S
机构：
[1] UNIV FLORENCE,DEPT NEUROL & PSYCHIAT SCI,I-50134 FLORENCE,ITALY
[2] ASSOC L PETRUZZI,CASA CURA VILLA SERENA,PESCARA,ITALY
来源：
ANNALS OF NEUROLOGY | 1996年 / 40卷 / 04期
关键词：
D O I：
10.1002/ana.410400420
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
A recent observation has shown thar a common polymorphism in the alpha(1)-antichymotrypsin (ACT) gene modifies the apolipoprotein E (ApoE) epsilon 4-associated Alzheimer's disease (AD) risk identifying the combination of the ACT/AA. and ApoE epsilon 4/epsilon 4 genotypes as a potential susceptibility marker for AD, We analyzed the segregation of the ApoE and ACT polymorphism in sporadic and familial AD patients. in none of the sporadic AD patients did we find the combination of the ACT/AA, and ApoE epsilon 4/epsilon 4 genotypes. The frequency of ApoE epsilon 4/epsilon 4 homozygosity in the AD sample resulted highest far the ACT/TT genotype (17.6%). Our data fail to confirm any additional association with AD beyond the ApoE epsilon 4 allele with any ACT genotype, suggesting that ACT does not represent an additional risk factor for AD.
引用
收藏
页码：678 / 680
页数：3
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