Effects of sex hormone disturbances on craniofacial growth in newborn mice

被引：48

作者：

Fujita, T ^{[1
]}

Ohtani, J ^{[1
]}

Shigekawa, M ^{[1
]}

Kawata, T ^{[1
]}

Kaku, M ^{[1
]}

Kohno, S ^{[1
]}

Tsutsui, K ^{[1
]}

Tenjo, K ^{[1
]}

Motokawa, M ^{[1
]}

Tohma, Y ^{[1
]}

Tanne, K ^{[1
]}

机构：

[1] Hiroshima Univ, Dept Orthodont & Craniofacial Dev Biol, Grad Sch Biomed Sci, Minami Ku, Hiroshima 7348553, Japan

来源：

JOURNAL OF DENTAL RESEARCH | 2004年 / 83卷 / 03期

关键词：

orchiectomy; ovariectomy; craniofacial growth; newborn mice;

D O I：

10.1177/154405910408300313

中图分类号：

R78 [口腔科学];

学科分类号：

1003 ;

摘要：

It is well-known that sex hormones influence bone metabolism. However it remains unclear as to, how sex hormones affect bone growth in newborn mice. In this study, we performed orchiectomy. (ORX) and ovariectomy (OVX) on newborn mice and examined the effects on craniofacial growth, morphometrically ORX and OVX were. performed on five-day-old C57BL/6J mice. Four weeks after surgery lateral cephalograms were, taken of all of the mice with the use of a rat and, mouse cephalometer. Cephalometric analysis of the craniofacial skeleton was performed by means of a personal computer. Inhibition of craniofacial growth was found in the experimental groups but not in the sham-operated groups. In the nasomaxillary bone and mandible the amount of growth was significantly reduced. These results suggest that cramofacial growth is inhibited by sex hormone disturbances not only in puberty but also immediately after birth.

引用

页码：250 / 254

页数：5

共 20 条

[1] RESTRICTED GROWTH AT THE FRONTONASAL SUTURE - ALTERATIONS IN CRANIOFACIAL GROWTH IN RABBITS
BABLER, WJ
PERSING, JA
NAGORSKY, MJ
JANE, JA
[J]. AMERICAN JOURNAL OF ANATOMY, 1987, 178 (01): : 90 - 98
[2] REGULATION OF INTERLEUKIN-6, OSTEOCLASTOGENESIS, AND BONE MASS BY ANDROGENS THE ROLE OF THE ANDROGEN RECEPTOR
BELLIDO, T
JILKA, RL
BOYCE, BF
GIRASOLE, G
BROXMEYER, H
DALRYMPLE, SA
MURRAY, R
MANOLAGAS, SC
[J]. JOURNAL OF CLINICAL INVESTIGATION, 1995, 95 (06) : 2886 - 2895
[3] EVIDENCE OF ESTROGEN-RECEPTORS IN NORMAL HUMAN OSTEOBLAST-LIKE CELLS
ERIKSEN, EF
COLVARD, DS
BERG, NJ
GRAHAM, ML
MANN, KG
SPELSBERG, TC
RIGGS, BL
[J]. SCIENCE, 1988, 241 (4861) : 84 - 86
[4] INCREASES IN BONE-DENSITY DURING TREATMENT OF MEN WITH IDIOPATHIC HYPOGONADOTROPIC HYPOGONADISM
FINKELSTEIN, JS
KLIBANSKI, A
NEER, RM
DOPPELT, SH
ROSENTHAL, DI
SEGRE, GV
CROWLEY, WF
[J]. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1989, 69 (04) : 776 - 783
[5] Fujita T, 2001, Clin Orthod Res, V4, P172, DOI 10.1034/j.1600-0544.2001.040307.x
[6] Influence of oestrogen and androgen on modelling of the mandibular condylar bone in ovariectomized and orchiectomized growing mice
Fujita, T
Kawata, T
Tokimasa, C
Tanne, K
[J]. ARCHIVES OF ORAL BIOLOGY, 2001, 46 (01) : 57 - 65
[7] THE RELATIONSHIP BETWEEN MASTICATORY FUNCTION AND CRANIOFACIAL MORPHOLOGY .1. A CEPHALOMETRIC LONGITUDINAL ANALYSIS IN THE GROWING-RAT FED A SOFT DIET
KILIARIDIS, S
ENGSTROM, C
THILANDER, B
[J]. EUROPEAN JOURNAL OF ORTHODONTICS, 1985, 7 (04) : 273 - 283
[8] IMMUNOCYTOCHEMICAL IDENTIFICATION OF ANDROGEN RECEPTOR IN MOUSE OSTEOCLAST-LIKE MULTINUCLEATED CELLS
MIZUNO, Y
HOSOI, T
INOUE, S
IKEGAMI, A
KANEKI, M
AKEDO, Y
NAKAMURA, T
OUCHI, Y
CHANG, C
ORIMO, H
[J]. CALCIFIED TISSUE INTERNATIONAL, 1994, 54 (04) : 325 - 326
[9] AROMATASE DEFICIENCY IN MALE AND FEMALE SIBLINGS CAUSED BY A NOVEL MUTATION AND THE PHYSIOLOGICAL-ROLE OF ESTROGENS
MORISHIMA, A
GRUMBACH, MM
SIMPSON, ER
FISHER, C
QIN, K
[J]. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1995, 80 (12) : 3689 - 3698
[10] GENDER DEPENDENT EFFECTS OF TESTOSTERONE AND 17-BETA-ESTRADIOL ON BONE-GROWTH AND MODELING IN YOUNG MICE
ORNOY, A
GIRON, S
ANER, R
GOLDSTEIN, M
BOYAN, BD
SCHWARTZ, Z
[J]. BONE AND MINERAL, 1994, 24 (01): : 43 - 58

← 1 2 →