Effects of sex hormone disturbances on craniofacial growth in newborn mice

被引：50

作者：

Fujita, T ^{[1
]}

Ohtani, J ^{[1
]}

Shigekawa, M ^{[1
]}

Kawata, T ^{[1
]}

Kaku, M ^{[1
]}

Kohno, S ^{[1
]}

Tsutsui, K ^{[1
]}

Tenjo, K ^{[1
]}

Motokawa, M ^{[1
]}

Tohma, Y ^{[1
]}

Tanne, K ^{[1
]}

机构：

[1] Hiroshima Univ, Dept Orthodont & Craniofacial Dev Biol, Grad Sch Biomed Sci, Minami Ku, Hiroshima 7348553, Japan

来源：

JOURNAL OF DENTAL RESEARCH | 2004年 / 83卷 / 03期

关键词：

orchiectomy; ovariectomy; craniofacial growth; newborn mice;

D O I：

10.1177/154405910408300313

中图分类号：

R78 [口腔科学];

学科分类号：

1003 ;

摘要：

It is well-known that sex hormones influence bone metabolism. However it remains unclear as to, how sex hormones affect bone growth in newborn mice. In this study, we performed orchiectomy. (ORX) and ovariectomy (OVX) on newborn mice and examined the effects on craniofacial growth, morphometrically ORX and OVX were. performed on five-day-old C57BL/6J mice. Four weeks after surgery lateral cephalograms were, taken of all of the mice with the use of a rat and, mouse cephalometer. Cephalometric analysis of the craniofacial skeleton was performed by means of a personal computer. Inhibition of craniofacial growth was found in the experimental groups but not in the sham-operated groups. In the nasomaxillary bone and mandible the amount of growth was significantly reduced. These results suggest that cramofacial growth is inhibited by sex hormone disturbances not only in puberty but also immediately after birth.

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页码：250 / 254

页数：5

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