A Ratiometric Near-Infrared Fluorescent Probe for Hydrazine and Its in Vivo Applications

被引：215
|
作者：
Hu, Chong [1 ]
Sun, Wen [1 ]
Cao, Jianfang [1 ]
Gao, Pan [1 ]
Wang, Jingyun [1 ]
Fan, Jiangli [1 ]
Song, Fengling [1 ]
Sun, Shiguo [1 ]
Peng, Xiaojun [1 ]
机构：
[1] Dalian Univ Technol, State Key Lab Fine Chem, Dalian 116024, Peoples R China
来源：
ORGANIC LETTERS | 2013年 / 15卷 / 15期
基金：
国家高技术研究发展计划(863计划); 美国国家科学基金会;
关键词：
HYDROGEN-SULFIDE; OXIDATION; SENSOR; GOLD;
D O I：
10.1021/ol401838p
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Based on modulation of the conjugated polymethine pi-electron system of a cyanine dye derivative, a ratiometric near-infared fluorescent probe (Cy7A) for hydrazine (N2H4) has been designed and synthesized. Cy7A can be selectively hydrazinolysized with great changes in its fluorescent excitation/emission profiles, which makes it possible to detect N2H4 in water samples and living cells and, for the first time, visualize N2H4 in living mice.
引用
收藏
页码：4022 / 4025
页数：4
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