A Ratiometric Near-Infrared Fluorescent Probe for Hydrazine and Its in Vivo Applications

被引：217

作者：

Hu, Chong ^{[1
]}

Sun, Wen ^{[1
]}

Cao, Jianfang ^{[1
]}

Gao, Pan ^{[1
]}

Wang, Jingyun ^{[1
]}

Fan, Jiangli ^{[1
]}

Song, Fengling ^{[1
]}

Sun, Shiguo ^{[1
]}

Peng, Xiaojun ^{[1
]}

机构：

[1] Dalian Univ Technol, State Key Lab Fine Chem, Dalian 116024, Peoples R China

来源：

ORGANIC LETTERS | 2013年 / 15卷 / 15期

基金：

美国国家科学基金会; 国家高技术研究发展计划(863计划);

关键词：

HYDROGEN-SULFIDE; OXIDATION; SENSOR; GOLD;

D O I：

10.1021/ol401838p

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Based on modulation of the conjugated polymethine pi-electron system of a cyanine dye derivative, a ratiometric near-infared fluorescent probe (Cy7A) for hydrazine (N2H4) has been designed and synthesized. Cy7A can be selectively hydrazinolysized with great changes in its fluorescent excitation/emission profiles, which makes it possible to detect N2H4 in water samples and living cells and, for the first time, visualize N2H4 in living mice.

引用

页码：4022 / 4025

页数：4

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