Sodium Hydroxide Catalyzed N-Alkylation of (Hetero) Aromatic Primary Amines and N1,C5-Dialkylation of 4-Phenyl-2-aminothiazoles with Benzyl Alcohols

被引：21

作者：

Donthiri, Ramachandra Reddy ^{[1
]}

Pappula, Venkatanarayana ^{[1
]}

Mohan, Darapaneni Chandra ^{[1
]}

Gaywala, Hiren H. ^{[1
]}

Adimurthy, Subbarayappa ^{[1
]}

机构：

[1] CSIR Cent Salt & Marine Chem Res Inst, Acad Sci & Innovat Res, Bhavnagar 364002, Gujarat, India

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2013年 / 78卷 / 13期

关键词：

AEROBIC OXIDATION; DERIVATIVES; IMINES;

D O I：

10.1021/jo400834h

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

In the presence of a catalytic amount of NaOH, the selective N-alkylation of various heteroaromatic primary amines is reported. With 1 equiv of NaOH, N-1,C-5-dialkylation of 4-phenyl-2-aminothiazoles has been investigated. Reaction of in situ generated aldehyde with amine yields the N-alkylated and N-1,C-5-dialkylated products through hydride ion transformation from alcohol.

引用

页码：6775 / 6781

页数：7

共 3 条

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