Identifying distinct trajectories of change in young breast cancer survivors' sexual functioning

被引：19

作者：

von Hippel, Christiana ^{[1
,2
]}

Rosenberg, Shoshana M. ^{[1
,3
]}

Austin, S. Bryn ^{[2
,3
]}

Sprunck-Harrild, Kim ^{[1
]}

Ruddy, Kathryn J. ^{[4
]}

Schapira, Lidia ^{[5
]}

Come, Steven ^{[3
,6
]}

Borges, Virginia F. ^{[7
]}

Partridge, Ann H. ^{[1
,3
]}

机构：

[1] Dana Farber Canc Inst, Div Med Oncol, Boston, MA 02115 USA

[2] Harvard TH Chan Sch Publ Hlth, Dept Social & Behav Sci, Boston, MA USA

[3] Harvard Med Sch, Dept Med, Boston, MA 02115 USA

[4] Mayo Clin, Div Med Oncol, Rochester, MN USA

[5] Stanford Univ, Med Ctr, Dept Med Oncol, Stanford, CA 94305 USA

[6] Beth Israel Deaconess Med Ctr, Breast Canc Program, Boston, MA 02215 USA

[7] Univ Colorado, Div Med Oncol, Aurora, CO USA

来源：

PSYCHO-ONCOLOGY | 2019年 / 28卷 / 05期

关键词：

breast cancer; cancer; cancer survivorship; oncology; quality of life; sexual dysfunction; sexual functioning; trajectory analysis; young women; QUALITY-OF-LIFE; SURGICAL ADJUVANT BREAST; PREMENOPAUSAL WOMEN; OVARIAN-FUNCTION; HEALTH; TAMOXIFEN; CHEMOTHERAPY; SUPPRESSION; PREVENTION; CARCINOMA;

D O I：

10.1002/pon.5047

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Objectives To identify and characterize distinct trajectories of change in young women's sexual functioning over the first 5 years following breast cancer diagnosis. Methods Group-based trajectory modeling was applied to the sexual functioning of 896 women diagnosed with stage I-IV breast cancer at age 40 or younger. The Cancer Rehabilitation Evaluation System was used to evaluate women's symptoms of sexual dysfunction annually for 5 years. Results Five distinct trajectories of sexual functioning were identified: one asymptomatic, one minimally symptomatic, two moderately symptomatic, and one severely symptomatic trajectory. Twelve percent of women were asymptomatic throughout follow-up. The plurality of women experienced stable mild symptoms (42%). Among those with moderate symptoms, some experienced improvement over time (22%) while others experienced deterioration (13%); 11% experienced stable severe symptoms that did not remit over time. Independent predictors of experiencing a symptomatic rather than asymptomatic trajectory (P < 0.05, two-sided) included diagnosis with stage 2 versus 1 disease, ER positive disease treated with oophorectomy or ovarian suppression, being partnered, having anxiety, poorer body image, and greater musculoskeletal pain. Conclusions We identified distinct trajectories that describe the reported sexual symptoms in this cohort of young breast cancer survivors. The majority of women reported various degrees of sexual dysfunction that remained stable over the study period. There is, however, potential for improvement of moderate and severe symptoms of sexual dysfunction in early survivorship.

引用

页码：1033 / 1040

页数：8