Precision medicine and phenotypes, endotypes, genotypes, regiotypes, and theratypes of allergic diseases

被引：225

作者：

Agache, Ioana ^{[1
]}

Akdis, Cezmi A. ^{[2
,3
]}

机构：

[1] Transylvania Univ, Fac Med, Brasov, Romania

[2] Univ Zurich, Swiss Inst Allergy & Asthma Res SIAF, Davos, Switzerland

[3] Christine Kuhne Ctr Allergy Res & Educ CK CARE, Davos, Switzerland

来源：

JOURNAL OF CLINICAL INVESTIGATION | 2019年 / 129卷 / 04期

基金：

瑞士国家科学基金会;

关键词：

EPITHELIAL BARRIER DYSFUNCTION; BITTER TASTE RECEPTORS; INNATE LYMPHOID-CELLS; CHRONIC RHINOSINUSITIS; INHALED CORTICOSTEROIDS; ASTHMA PHENOTYPES; GENE-EXPRESSION; INDUCED SPUTUM; TH17; CELLS; T-CELLS;

D O I：

10.1172/JCI124611

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

A rapidly developing paradigm for modern health care is a proactive and individualized response to patients' symptoms, combining precision diagnosis and personalized treatment. Precision medicine is becoming an overarching medical discipline that will require a better understanding of biomarkers, phenotypes, endotypes, genotypes, regiotypes, and theratypes of diseases. The 100-year-old personalized allergen-specific management of allergic diseases has particularly contributed to early awareness in precision medicine. Polyomics, big data, and systems biology have demonstrated a profound complexity and dynamic variability in allergic disease between individuals, as well as between regions. Escalating health care costs together with questionable efficacy of the current management of allergic diseases facilitated the emergence of the endotype-driven approach. We describe here a precision medicine approach that stratifies patients based on disease mechanisms to optimize management of allergic diseases.

引用

收藏

页码：1493 / 1503

页数：11

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