The Role of Uterine NK Cells in Normal Reproduction and Reproductive Disorders

被引：27

作者：

Bulmer, Judith N. ^{[1
]}

Lash, Gendie E. ^{[1
]}

机构：

[1] Newcastle Univ, Inst Cellular Med, Reprod & Vasc Biol Grp, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England

来源：

MALE ROLE IN PREGNANCY LOSS AND EMBRYO IMPLANTATION FAILURE | 2015年 / 868卷

关键词：

Endometrial leucocyte; Uterine NK cells; T lymphocytes; CD56; Cytokines; Chemokines; Extravillous trophoblast; Angiogenic growth factors; Miscarriage; Preeclampsia; NATURAL-KILLER-CELLS; ANGIOGENIC GROWTH-FACTORS; REGULATORY T-CELLS; ENDOMETRIAL GRANULATED LYMPHOCYTES; EXTRAVILLOUS TROPHOBLAST INVASION; DECIDUAL LEUKOCYTE POPULATIONS; RECURRENT SPONTANEOUS-ABORTION; ANTIGEN-PRESENTING CELLS; FETAL HLA-C; IMMUNE CELLS;

D O I：

10.1007/978-3-319-18881-2_5

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The human endometrium contains a substantial population of leucocytes which vary in distribution during the menstrual cycle and pregnancy. An unusual population of natural killer (NK) cells, termed uterine NK (uNK) cells, are the most abundant of these cells in early pregnancy. The increase in number of uNK cells in the mid-secretory phase of the cycle with further increases in early pregnancy has focused attention on the role of uNK cells in early pregnancy. Despite many studies, the in vivo role of these cells is uncertain. This chapter reviews current information regarding the role of uNK cells in healthy human pregnancy and evidence indicating their importance in various reproductive and pregnancy problems. Studies in humans are limited by the availability of suitable tissues and the limitations of extrapolation from animal models.

引用

页码：95 / 126

页数：32

共 190 条

[1] Interleukin-11 signaling is required for the differentiation of natural killer cells at the maternal-fetal interface [J].