CXCL10 in psoriasis

被引：53

作者：

Ferrari, Silvia Martina ^{[1
]}

Ruffilli, Ilaria ^{[1
]}

Colaci, Michele ^{[2
]}

Antonelli, Alessandro ^{[1
]}

Ferri, Clodoveo ^{[2
]}

Fallahi, Poupak ^{[1
]}

机构：

[1] Univ Pisa, Dept Clin & Expt Med, I-56126 Pisa, Italy

[2] Univ Modena & Reggio Emilia, Azienda Osped Univ, Policlin Modena, Rheumatol Unit,Med Sch, Modena, Italy

来源：

ADVANCES IN MEDICAL SCIENCES | 2015年 / 60卷 / 02期

关键词：

CXCL10; Psoriasis; Autoimmunity; CXCR3; GAMMA-INDUCED PRODUCTION; ALPHA-CHEMOKINE CXCL10; CCL2; SERUM-LEVELS; MIXED CRYOGLOBULINEMIA; THYROID-CANCER; HIGH VALUES; INDUCIBLE PROTEIN-10; ENDOTHELIAL FUNCTION; HUMAN KERATINOCYTES; SYSTEMIC-SCLEROSIS;

D O I：

10.1016/j.advms.2015.07.011

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Chemokine (C-X-C motif) ligand (CXCL)10 is involved in the pathogenesis of psoriasis. It has been demonstrated that chemokine (C-X-C motif) receptors (CXCR)3 and CXCL10 were detected in keratinocytes and the dermal infiltrate obtained from active psoriatic plaques and that successful treatment of active plaques decreased the expression of CXCL10. Elevated CXCL10 serum levels have been shown in patients with psoriasis, with a type 1 T helper cells immune predominance at the beginning of the disease, while a decline of this chemokine has been evidenced later, in long lasting psoriasis. Circulating CXCL10 is significantly higher in patients with psoriasis in the presence of autoimmune thyroiditis. It has been hypothesized that CXCL10 could be a good marker to monitor the activity or progression of psoriasis. Efforts have been made to modulate or inhibit the CXCR3/CXCL10 axis in psoriasis to modify the course of the disease. (C) 2015 Published by Elsevier Sp. z o.o.

引用

页码：349 / 354

页数：6

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