SPLUNC1 Regulates Cell Progression and Apoptosis through the miR-141-PTEN/p27 Pathway, but Is Hindered by LMP1

被引：19

作者：

Chen, Pan ^{[1
,2
,3
,4
]}

Guo, Xiaofang ^{[3
,4
]}

Zhou, Houde ^{[3
,4
]}

Zhang, Wenling ^{[3
,4
]}

Zeng, Zhaoyang ^{[1
,2
,3
,4
,5
,6
]}

Liao, Qianjin ^{[3
,4
]}

Li, Xiayu ^{[5
,6
]}

Xiang, Bo ^{[1
,2
,3
,4
,5
]}

Yang, Jianbo ^{[6
,7
,8
]}

Ma, Jian ^{[1
,2
,3
,4
,5
,6
]}

Zhou, Ming ^{[1
,2
,3
,4
,5
,6
]}

Peng, Shuping ^{[1
,2
,3
,4
,5
,6
]}

Xiang, Juanjuan ^{[1
,2
,3
,4
,5
,6
]}

Li, Xiaoling ^{[1
,2
,3
,4
,5
]}

Le, Colvin Wanshura ^{[7
,8
]}

Xiong, Wei ^{[1
,2
,3
,4
,5
,6
]}

McCarthy, James B. ^{[7
,8
]}

Li, Guiyuan ^{[1
,2
,3
,4
,5
,6
]}

机构：

[1] Cent S Univ, Hunan Prov Tumor Hosp, Changsha, Hunan, Peoples R China

[2] Cent S Univ, Xiangya Med Sch, Affiliated Tumor Hosp, Changsha, Hunan, Peoples R China

[3] Cent S Univ, Key Lab Carcinogenesis, Minist Hlth, Canc Res Inst, Changsha, Hunan, Peoples R China

[4] Cent S Univ, Key Lab Carcinogenesis & Canc Invas, Canc Res Inst, Minist Educ, Changsha, Hunan, Peoples R China

[5] Cent S Univ, Xiangya Hosp 3, Hunan Key Lab Nonresolving Inflammat, Changsha, Hunan, Peoples R China

[6] Cent S Univ, Xiangya Hosp 3, Canc & Dis Genome Res Ctr, Changsha, Hunan, Peoples R China

[7] Univ Minnesota, Dept Lab Med & Pathol, Minneapolis, MN 55455 USA

[8] Univ Minnesota, Masonic Canc Ctr, Minneapolis, MN 55455 USA

来源：

PLOS ONE | 2013年 / 8卷 / 03期

基金：

国家高技术研究发展计划(863计划); 中国国家自然科学基金;

关键词：

EPSTEIN-BARR-VIRUS; NF-KAPPA-B; NASOPHARYNGEAL CARCINOMA; SUSCEPTIBILITY LOCUS; CDNA MICROARRAY; INHERITED BREAST; CHROMOSOME; 3P21; HOST-DEFENSE; PROTEIN; GENE;

D O I：

10.1371/journal.pone.0056929

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Little is known about the role of the host defensive protein short palate, lung and nasal epithelium clone 1 (SPLUNC1) in the carcinogenesis of nasopharyngeal carcinoma (NPC). Here we report that SPLUNC1 plays a role at a very early stage of NPC carcinogenesis. SPLUNC1 regulates NPC cell proliferation, differentiation and apoptosis through miR-141, which in turn regulates PTEN and p27 expression. This signaling axis is negatively regulated by the EBV-coded gene LMP1. Therefore we propose that SPLUNC1 suppresses NPC tumor formation and its inhibition by LMP1 provides a route for NPC tumorigenesis.

引用

页数：12

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