The relationship between colorectal cancer risk factors and LINE-1 DNA methylation in healthy colon tissue

被引：3

作者：

Gogna, Priyanka ^{[1
]}

King, Will D. ^{[1
]}

机构：

[1] Queens Univ, Dept Publ Hlth Sci, Kingston, ON K7K 3N6, Canada

来源：

EPIGENOMICS | 2020年 / 12卷 / 13期

关键词：

adenoma; colorectal cancer; DNA methylation; fruit and vegetable consumption; LINE-1; NSAID; CIGARETTE-SMOKING; OXIDATIVE STRESS; FOLATE STATUS; BLOOD; INFLAMMATION; BIOMARKERS; ADENOMA; MUCOSA;

D O I：

10.2217/epi-2019-0340

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Aim:LINE-1 DNA methylation is a modifiable epigenetic process linked to colorectal cancer (CRC). However, studies of methylation in the tissue of interest are limited. This research examines associations between CRC risk factors and LINE-1 DNA methylation in healthy colon tissue.Materials & methods:LINE-1 methylation was measured in colon tissue samples from 317 patients undergoing a screening colonoscopy. Associations were examined with established CRC risk factors including alcohol consumption, smoking, BMI, NSAIDs, physical activity and fruit and vegetable consumption.Results:All studied risk factors were not related to LINE-1 DNA methylation in this population.Conclusion:The observed results may reflect that the effect of this set of established risk factors is not mediated through LINE-1 DNA methylation in the healthy colon.

引用

页码：1087 / 1093

页数：8

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