Hirsutalins I-M, eunicellin-based diterpenoids from the soft coral Cladiella hirsuta

被引：18

作者：

Chen, Bo-Wei ^{[1
,7
]}

Wang, Sheng-Yang ^{[2
]}

Huang, Chiung-Yao ^{[1
]}

Chen, Shu-Li ^{[3
]}

Wu, Yang-Chang ^{[3
,4
,5
,6
]}

Sheu, Jyh-Horng ^{[1
,7
]}

机构：

[1] Natl Sun Yat Sen Univ, Dept Marine Biotechnol & Resources, Kaohsiung 804, Taiwan

[2] Natl Chung Hsing Univ, Dept Forestry, Taichung 402, Taiwan

[3] Kaohsiung Med Univ, Grad Inst Nat Prod, Kaohsiung 807, Taiwan

[4] China Med Univ, Coll Chinese Med, Sch Chinese Med, Taichung 404, Taiwan

[5] China Med Univ Hosp, Nat Med Prod Res Ctr, Taichung 404, Taiwan

[6] China Med Univ Hosp, Ctr Mol Med, Taichung 404, Taiwan

[7] Natl Sun Yat Sen Univ, Asia Pacific Ocean Res Ctr, Kaohsiung 804, Taiwan

来源：

TETRAHEDRON | 2013年 / 69卷 / 10期

关键词：

Eunicellin-base diterpenoids; Hirsutalins I-M; Cytotoxicity; NO inhibitory activity; ABSOLUTE-CONFIGURATION; NMR APPLICATION; MOSHER METHOD; A-D; AUSTRALIS;

D O I：

10.1016/j.tet.2013.01.015

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

New eunicellin-base diterpenoids, hirsutalins I-M (1-5), were isolated from the soft coral Cladiella hirsuta. Their structures were elucidated by spectroscopic methods, particularly in 1D and 2D NMR experiments. The absolute configuration of 2 was determined by Mosher's method. These compounds did not exhibit cytotoxicity toward a limited panel of cancer cell lines but showed nitric oxide inhibitory activity in LPS-stimulated RAW264.7 macrophage cells. Among them, compound 3 was found to possess the strongest NO inhibitory activity with an IC50 value of 9.8 mu g/mL. Furthermore, 3 was shown to significantly reduce the expression iNOS protein in the same cells. (C) 2013 Elsevier Ltd. All rights reserved.

引用

页码：2296 / 2301

页数：6

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