Synthesis of a novel series of fluoroarene derivatives of artemisinin as potent antifungal and anticancer agent

被引：19

作者：

Buragohain, Pori ^{[1
]}

Surineni, Naresh ^{[1
]}

Barua, Nabin C. ^{[1
]}

Bhuyan, Purnajyoti D. ^{[1
]}

Boruah, Paran ^{[1
]}

Borah, Jagat C. ^{[2
]}

Laisharm, Surbala ^{[2
]}

Moirangthem, Dinesh Singh ^{[2
]}

机构：

[1] CSIR, North East Inst Sci & Technol, Jorhat 785006, Assam, India

[2] Inst Bioresources & Sustainable Dev, Imphal 795001, Manipur, India

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2015年 / 25卷 / 16期

关键词：

Artemisinin; Antifungal; Anticancer; Fusarium oxysporum; Suzuki cross-coupling; DIMERS; ANTIMALARIAL; DIHYDROARTEMISININ; GROWTH;

D O I：

10.1016/j.bmcl.2015.05.067

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of new fluoroarene derivatives of artemisinin were prepared using Suzuki and Sonogashira cross-coupling reactions. An antifungal and antitumor activity was evaluated against opportunistic pathogen Fusarium oxysporum and Hela cancer cell line. All these derivatives have shown moderate to good activity. (C) 2015 Elsevier Ltd. All rights reserved.

引用

页码：3338 / 3341

页数：4

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