Treatment of Chronic Lymphocytic Leukemia

被引：182

作者：

Burger, Jan A. ^{[1
]}

机构：

[1] Univ Texas MD Anderson Canc Ctr, Dept Leukemia, Unit 428, Houston, TX 77030 USA

来源：

NEW ENGLAND JOURNAL OF MEDICINE | 2020年 / 383卷 / 05期

关键词：

B-CELL RECEPTOR; BRUTONS TYROSINE KINASE; PREVIOUSLY UNTREATED PATIENTS; HIGH-LEVEL EXPRESSION; GENE MUTATION STATUS; OPEN-LABEL; IBRUTINIB THERAPY; CLONAL EVOLUTION; INITIAL THERAPY; CD38; EXPRESSION;

D O I：

10.1056/NEJMra1908213

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Treatment of CLL, the most common leukemia in the West, has undergone a revolution in the past few years with the development of agents that target signaling kinases and cell-survival mediators. Survival even among patients with a poor prognosis now exceeds 8 years.

引用

页码：460 / 473

页数：14

共 93 条

[1] Depth and durability of response to ibrutinib in CLL: 5-year follow-up of a phase 2 study [J].

Ahn, Inhye E. ;

Farooqui, Mohammed Z. H. ;

Tian, Xin ;

Valdez, Janet ;

Sun, Clare ;

Soto, Susan ;

Lotter, Jennifer ;

Housel, Stephanie ;

Stetler-Stevenson, Maryalice ;

Yuan, Constance M. ;

Maric, Irina ;

Calvo, Katherine R. ;

Nierman, Pia ;

Hughes, Thomas E. ;

Saba, Nakhle S. ;

Marti, Gerald E. ;

Pittaluga, Stefania ;

Herman, Sarah E. M. ;

Niemann, Carsten U. ;

Pedersen, Lone B. ;

Geisler, Christian H. ;

Childs, Richard ;

Aue, Georg ;

Wiestner, Adrian .

BLOOD, 2018, 131 (21) :2357-2366

[2] Clonal evolution leading to ibrutinib resistance in chronic lymphocytic leukemia [J].

Ahn, Inhye E. ;

Underbayev, Chingiz ;

Albitar, Adam ;

Herman, Sarah E. M. ;

Tian, Xin ;

Maric, Irina ;

Arthur, Diane C. ;

Wake, Laura ;

Pittaluga, Stefania ;

Yuan, Constance M. ;

Stetler-Stevenson, Maryalice ;

Soto, Susan ;

Valdez, Janet ;

Nierman, Pia ;

Lotter, Jennifer ;

Xi, Liqiang ;

Raffeld, Mark ;

Farooqui, Mohammed ;

Albitar, Maher ;

Wiestner, Adrian .

BLOOD, 2017, 129 (11) :1469-1479

[3]

[Anonymous], 2017, LANCET HIV, V2, pe115

[4]

BINET JL, 1981, CANCER-AM CANCER SOC, V48, P198, DOI 10.1002/1097-0142(19810701)48:1<198::AID-CNCR2820480131>3.0.CO

[5]

2-V

[6] Multiple BCL2 mutations cooccurring with Gly101Val emerge in chronic lymphocytic leukemia progression on venetoclax [J].

Blombery, Piers ;

Thompson, Ella R. ;

Tamia Nguyen ;

Birkinshaw, Richard W. ;

Gong, Jia-Nan ;

Chen, Xiangting ;

McBean, Michelle ;

Thijssen, Rachel ;

Conway, Thomas ;

Anderson, Mary Ann ;

Seymour, John F. ;

Westerman, David A. ;

Czabotar, Peter E. ;

Huang, David C. S. ;

Roberts, Andrew W. .

BLOOD, 2020, 135 (10) :773-+

[7] Incidence of and risk factors for major haemorrhage in patients treated with ibrutinib: An integrated analysis [J].

Brown, Jennifer R. ;

Moslehi, Javid ;

Ewer, Michael S. ;

O'Brien, Susan M. ;

Ghia, Paolo ;

Cymbalista, Florence ;

Shanafelt, Tait D. ;

Fraser, Graeme ;

Rule, Simon ;

Coutre, Steven E. ;

Dilhuydy, Marie-Sarah ;

Cramer, Paula ;

Jaeger, Ulrich ;

Dreyling, Martin ;

Byrd, John C. ;

Treon, Steven ;

Liu, Emily Y. ;

Chang, Stephen ;

Bista, Amulya ;

Vempati, Rama ;

Boornazian, Lisa ;

Valentino, Rudolph ;

Reddy, Vijay ;

Mahler, Michelle ;

Yang, Huiying ;

Graef, Thorsten ;

Burger, Jan A. .

BRITISH JOURNAL OF HAEMATOLOGY, 2019, 184 (04) :558-569

[8] Characterization of atrial fibrillation adverse events reported in ibrutinib randomized controlled registration trials [J].

Brown, Jennifer R. ;

Moslehi, Javid ;

O'Brien, Susan ;

Ghia, Paolo ;

Hillmen, Peter ;

Cymbalista, Florence ;

Shanafelt, Tait D. ;

Fraser, Graeme ;

Rule, Simon ;

Kipps, Thomas J. ;

Coutre, Steven ;

Dilhuydy, Marie-Sarah ;

Cramer, Paula ;

Tedeschi, Alessandra ;

Jaeger, Ulrich ;

Dreyling, Martin ;

Byrd, John C. ;

Howes, Angela ;

Todd, Michael ;

Vermeulen, Jessica ;

James, Danelle F. ;

Clow, Fong ;

Styles, Lori ;

Valentino, Rudy ;

Wildgust, Mark ;

Mahler, Michelle ;

Burger, Jan A. .

HAEMATOLOGICA, 2017, 102 (10) :1796-1805

[9] Idelalisib, an inhibitor of phosphatidylinositol 3-kinase p110δ, for relapsed/refractory chronic lymphocytic leukemia [J].

Brown, Jennifer R. ;

Byrd, John C. ;

Coutre, Steven E. ;

Benson, Don M. ;

Flinn, Ian W. ;

Wagner-Johnston, Nina D. ;

Spurgeon, Stephen E. ;

Kahl, Brad S. ;

Bello, Celeste ;

Webb, Heather K. ;

Johnson, Dave M. ;

Peterman, Sissy ;

Li, Daniel ;

Jahn, Thomas M. ;

Lannutti, Brian J. ;

Ulrich, Roger G. ;

Yu, Albert S. ;

Miller, Langdon L. ;

Furman, Richard R. .

BLOOD, 2014, 123 (22) :3390-3397

[10] Ibrutinib as Initial Therapy for Patients with Chronic Lymphocytic Leukemia [J].

Burger, J. A. ;

Tedeschi, A. ;

Barr, P. M. ;

Robak, T. ;

Owen, C. ;

Ghia, P. ;

Bairey, O. ;

Hillmen, P. ;

Bartlett, N. L. ;

Li, J. ;

Simpson, D. ;

Grosicki, S. ;

Devereux, S. ;

McCarthy, H. ;

Coutre, S. ;

Quach, H. ;

Gaidano, G. ;

Maslyak, Z. ;

Stevens, D. A. ;

Janssens, A. ;

Offner, F. ;

Mayer, J. ;

O'Dwyer, M. ;

Hellmann, A. ;

Schuh, A. ;

Siddiqi, T. ;

Polliack, A. ;

Tam, C. S. ;

Suri, D. ;

Cheng, M. ;

Clow, F. ;

Styles, L. ;

James, D. F. ;

Kipps, T. J. ;

Keating, Michael ;

Jen, Jie ;

Jindra, Pavel ;

Simkovic, Martin ;

Braester, Andrei ;

Ruchlemer, Rosa ;

Foa, Roberto ;

Semenzato, Gianpietro ;

Hawkins, Timothy ;

Atanasio, Carolina Moreno ;

Demirkan, Fatih ;

Kaynar, Leylagul ;

Pylypenko, Halyna ;

Fox, Christopher ;

Thirman, Michael ;

Campbell, Philip .

NEW ENGLAND JOURNAL OF MEDICINE, 2015, 373 (25) :2425-2437

← 1 2 3 4 5 6 7 8 9 10 →