Complex Regional Pain Syndrome, Current Concepts and Treatment Options

被引：65
作者：
Urits, Ivan [1 ]
Shen, Abra H. [2 ]
Jones, Mark R. [1 ]
Viswanath, Omar [1 ]
Kaye, Alan D. [3 ]
机构：
[1] Harvard Med Sch, Beth Israel Deaconess Med Ctr, Dept Anesthesiol Crit Care & Pain Med, Boston, MA USA
[2] Harvard Med Sch, Boston, MA USA
[3] Lousiana State Univ, Hlth Sci Ctr, Dept Anesthesiol, 1542 Tulane Ave,Suite 659, New Orleans, LA 70112 USA
来源：
CURRENT PAIN AND HEADACHE REPORTS | 2018年 / 22卷 / 02期
关键词：
Complex regional pain syndrome; CRPS-1; Disproportionate pain; Allodynia; Hyperalgesia; Budapest criteria; Spinal cord stimulation; SYNDROME TYPE-I; SPINAL-CORD STIMULATION; INTRAVENOUS IMMUNOGLOBULIN TREATMENT; ADJUVANT PHYSICAL-THERAPY; SYNDROME TYPE-1 CRPS1; INTRATHECAL BACLOFEN; VITAMIN-C; PSYCHOLOGICAL-FACTORS; OCCUPATIONAL-THERAPY; DIAGNOSTIC-CRITERIA;
D O I：
10.1007/s11916-018-0667-7
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Purpose of Review Complex regional pain syndrome (CRPS) refers to a chronic pain condition that is characterized by progressively worsening spontaneous regional pain without dermatomal distribution. The symptomatology includes pain out of proportion in time and severity to the inciting event. The purpose of this review is to present the most current information concerning epidemiology, diagnosis, pathophysiology, and therapy for CRPS. Recent Findings In recent years, discovery of pathophysiologic mechanisms of CRPS has led to significant strides in the understanding of the disease process. Summary Continued elucidation of the underlying pathophysiological mechanisms will allow for the development of more targeted and effective evidence-based therapy protocols. Further large clinical trials are needed to investigate mechanisms and treatment of the disorder.
引用
收藏
页数：9
相关论文
共 93 条
[1]   Pathologic alterations of cutaneous innervation and vasculature in affected limbs from patients with complex regional pain syndrome [J].
Albrecht, PJ ;
Hines, S ;
Eisenberg, E ;
Pud, D ;
Finlay, DR ;
Connolly, MK ;
Paré, M ;
Davar, G ;
Rice, FL .
PAIN, 2006, 120 (03) :244-266
[2]   Basal ganglia dysfunction in complex regional pain syndrome - A valid hypothesis? [J].
Azqueta-Gavaldon, M. ;
Schulte-Goecking, H. ;
Storz, C. ;
Azad, S. ;
Reiners, A. ;
Borsook, D. ;
Becerra, L. ;
Kraft, E. .
EUROPEAN JOURNAL OF PAIN, 2017, 21 (03) :415-424
[3]   Relationships Between Psychological Factors, Pain, and Disability in Complex Regional Pain Syndrome and Low Back Pain [J].
Bean, Debbie J. ;
Johnson, Malcolm H. ;
Kydd, Robert R. .
CLINICAL JOURNAL OF PAIN, 2014, 30 (08) :647-653
[4]   Low-dose Ketamine Improves Pain Relief in Patients Receiving Intravenous Opioids for Acute Pain in the Emergency Department: Results of a Randomized, Double-blind, Clinical Trial [J].
Beaudoin, Francesca L. ;
Lin, Charlie ;
Guan, Wentao ;
Merchant, Roland C. .
ACADEMIC EMERGENCY MEDICINE, 2014, 21 (11) :1194-1202
[5]   CNS Measures of Pain Responses Pre- and Post-Anesthetic Ketamine in a Patient with Complex Regional Pain Syndrome [J].
Becerra, L. ;
Schwartzman, R. J. ;
Kiefer, R. T. ;
Rohr, P. ;
Moulton, E. A. ;
Wallin, D. ;
Pendse, G. ;
Morris, S. ;
Borsook, David .
PAIN MEDICINE, 2015, 16 (12) :2368-2385
[6]   Demographic and medical parameters in the development of complex regional pain syndrome type 1 (CRPS1): Prospective study on 596 patients with a fracture [J].
Beerthuizen, Annemerle ;
Stronks, Dirk L. ;
van't Spijker, Adriaan ;
Yaksh, Ameeta ;
Hanraets, Barbara M. ;
Klein, Jan ;
Huygen, Frank J. P. M. .
PAIN, 2012, 153 (06) :1187-1192
[7]   The association between psychological factors and the development of complex regional pain syndrome type 1 (CRPS1) - A prospective multicenter study [J].
Beerthuizen, Annemerle ;
Stronks, Dirk L. ;
Huygen, Frank J. P. M. ;
Passchier, Jan ;
Klein, Jan ;
van't Spijker, Adriaan .
EUROPEAN JOURNAL OF PAIN, 2011, 15 (09) :971-975
[8]   Is there an association between psychological factors and the Complex Regional Pain Syndrome type 1 (CRPS1) in adults? A systematic review [J].
Beerthuizen, Annemerle ;
van't Spijker, Adriaan ;
Huygen, Frank J. P. M. ;
Klein, Jan ;
de Wit, Rianne .
PAIN, 2009, 145 (1-2) :52-59
[9]  
Bennett GJ, 2000, J PAIN SYMPTOM MANAG, V19, pS2
[10]   Complex regional pain syndrome-significant progress in understanding [J].
Birklein, Frank ;
Schlereth, Tanja .
PAIN, 2015, 156 (04) :S94-S103
12345678910