High prevalence of congenital heart disease at high altitudes in Tibet

被引:30
作者
Chun, Hua [1 ,2 ]
Yue, Yan [1 ,3 ]
Wang, Yibin [1 ,3 ]
Dawa, Zhaxi [2 ]
Zhen, Pu [2 ]
La, Qu [2 ]
Zong, Yang [2 ]
Qu, Yi [1 ,3 ]
Mu, Dezhi [1 ,3 ]
机构
[1] West China Second Univ Hosp, Dept Pediat, Chengdu, Sichuan, Peoples R China
[2] Tibet Univ, Sch Med, Lhasa, Peoples R China
[3] Sichuan Univ, Key Lab Birth Defects & Related Dis Women & Child, Chengdu, Sichuan, Peoples R China
基金
美国国家科学基金会;
关键词
Congenital heart disease; high altitude; prevalence; environmental risk factor;
D O I
10.1177/2047487318812502
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background Previous small sample studies suggested that elevated altitudes might be associated with the incidence of cardiovascular diseases. However, it remains uncertain whether high altitudes (over 3000 m above sea level) are related to congenital heart disease. We therefore explored the prevalence of congenital heart disease in a large cohort of students in the world's largest prefecture-level city with the highest altitude. Methods This cross-sectional study included 84,302 student participants (boys 52.12%, girls 47.88%, with an average age of 10.62 +/- 3.33 years). Data were extracted from the screening results among different altitude area schools in Nagqu from June 2016 to August 2017. Students were first screened by performing a physical examination consisting of cardiac auscultations and clinical manifestation screenings. An echocardiography was performed to confirm and identify the subtype of congenital heart disease. Results The prevalence of congenital heart disease among students in Nagqu, Tibet, was 5.21 parts per thousand (439 cases). The most common congenital heart disease type was patent ductus arteriosus, representing 66.3% of congenital heart diseases diagnosed in this study, followed by atrial septal defect and ventricular septal defect, representing 20.3% and 9.1% of congenital heart diseases, respectively. Students living in higher altitudes were significantly more prone to have congenital heart disease than students in locations with lower altitudes. The prevalence of congenital heart disease in girls was found to be higher than that of boys. Conclusions The correlation between congenital heart disease and increased altitude is noteworthy. This study's results are the first big data epidemiological investigation to confirm that high altitude is a significant environmental risk factor for congenital heart disease, especially patent ductus arteriosus. Furthermore, the results provide additional support to make a diagnostic and treatment plan to prevent congenital heart disease in high altitude areas.
引用
收藏
页码:756 / 759
页数:4
相关论文
共 8 条
[1]  
Department of Economic & Social Affairs, 2017, LEAST DEV COUNTR LDC
[2]   Increased arterial stiffness in children with congenital heart disease [J].
Haecker, Anna-Luisa ;
Reiner, Barbara ;
Oberhoffer, Renate ;
Hager, Alfred ;
Ewert, Peter ;
Mueller, Jan .
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY, 2018, 25 (01) :103-109
[3]   Genetic and environmental risk factors in congenital heart disease functionally converge in protein networks driving heart development [J].
Lage, Kasper ;
Greenway, Steven C. ;
Rosenfeld, Jill A. ;
Wakimoto, Hiroko ;
Gorham, Joshua M. ;
Segre, Ayellet V. ;
Roberts, Amy E. ;
Smoot, Leslie B. ;
Pu, William T. ;
Pereira, Alexandre C. ;
Mesquita, Sonia M. ;
Tommerup, Niels ;
Brunak, Soren ;
Ballif, Blake C. ;
Shaffer, Lisa G. ;
Donahoe, Patricia K. ;
Daly, Mark J. ;
Seidman, Jonathan G. ;
Seidman, Christine E. ;
Larsen, Lars A. .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2012, 109 (35) :14035-14040
[4]  
Matthews T J, 2015, Natl Vital Stat Rep, V64, P1
[5]  
State Council of the People's Republic of China, OFF REPL APPR TIB AU
[6]   Trends in Congenital Heart Disease The Next Decade [J].
Triedman, John K. ;
Newburger, Jane W. .
CIRCULATION, 2016, 133 (25) :2716-2733
[7]   Birth Prevalence of Congenital Heart Disease Worldwide A Systematic Review and Meta-Analysis [J].
van der Linde, Denise ;
Konings, Elisabeth E. M. ;
Slager, Maarten A. ;
Witsenburg, Maarten ;
Helbing, Willem A. ;
Takkenberg, Johanna J. M. ;
Roos-Hesselink, Jolien W. .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2011, 58 (21) :2241-2247
[8]   Altitude and cold weather: are they vascular risks? [J].
Whayne, Thomas F., Jr. .
CURRENT OPINION IN CARDIOLOGY, 2014, 29 (04) :396-402