Flavonoids from Tetrastigma obtectum enhancing glucose consumption in insulin-resistance HepG2 cells via activating AMPK

被引：26

作者：

Jin, Mei-Na ^{[1
]}

Shi, Guo-Ru ^{[1
]}

Tang, Sheng-An ^{[1
]}

Nan-Qin ^{[2
]}

Qiao, Wei ^{[1
]}

Duan, Hong-Quan ^{[1
,2
]}

机构：

[1] Tianjin Med Univ, Sch Pharm, Tianjin Key Lab Technol Enabling Dev Clin Therape, Tianjin 300070, Peoples R China

[2] Tianjin Med Univ, Res Ctr Basic Med Sci, Tianjin 300070, Peoples R China

来源：

FITOTERAPIA | 2013年 / 90卷

关键词：

Tetrastigma obtectum; Flavonoid; HepG2 glucose consumption; AMPK; PROTEIN-KINASE; LIPID-ACCUMULATION; QUERCETIN; EXTRACTS; MUSCLE; LEAVES;

D O I：

10.1016/j.fitote.2013.07.024

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Four new flavonoids including three C-glycosidic flavonoids, named tetrastigma A-D (1-4) and five known flavones (5-9) were isolated from the herbs of Tetrastigma obtectum (Wall.) Planch. The structures of 1-4 were elucidated by 1D- and 2D-NMR and HR mass spectrometric methods. Compound 1 caused significant enhancement in glucose consumption by insulin-resistant HepG2 cells compared with control cells. In addition, compound I stimulated phosphorylation of AMPK, which plays an important role in glycometabolism. (C) 2013 Elsevier B.V. All rights reserved.

引用

页码：240 / 246

页数：7

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