Amphiphilic Block Copolymer Films: Phase Transition, Stabilization, and Nanoscale Templates

被引:18
作者
Park, Jung Hyun [1 ,2 ]
Sun, Yujie [2 ,3 ]
Goldman, Yale E. [2 ,3 ]
Composto, Russell J. [1 ,2 ]
机构
[1] Univ Penn, Dept Mat Sci & Engn, Philadelphia, PA 19104 USA
[2] Univ Penn, Nano Bio Interface Ctr, Philadelphia, PA 19104 USA
[3] Univ Penn, Dept Physiol, Philadelphia, PA 19104 USA
基金
美国国家科学基金会;
关键词
FORCE MICROSCOPY; THIN-FILMS; ACTIN; CELL; ARRAYS; NANOSTRUCTURES; STIFFNESS; 3-AMINOPROPYLTRIETHOXYSILANE; ORIENTATION; FABRICATION;
D O I
10.1021/ma8023393
中图分类号
O63 [高分子化学(高聚物)];
学科分类号
070305 ; 080501 ; 081704 ;
摘要
A morphological transition of asymmetric poly(styrene-b-acrylic acid) (PS-b-PAA) films is observed by in situ scanning probe microscopy (SPM) in aqueous media. Upon initial exposure to buffer solution at pH 74, spherical PAA domains swell through a glassy PS surface layer to form negatively charged mushroom caps. With further exposure, the PAA caps coalesce to produce a smooth, highly wettable surface. However, if films are exposed to a buffer Solution containing 3-aminopropyltriethoxysilane (APTES) for I h, the PAA domain swelling is greatly reduced and the mushroom caps stabilize at a diameter of 33 nm. This stabilization results from a cross-linking reaction between PAA and APTES, which also converts the PAA domains from a net negative to net positive charge. By varying molecular weights of PAA block in PS-b-PAA, the feature size and spacing can he tuned. To demonstrate air application for this template with positively charged domains, a cytoskeletal filament. F-Actin with a net negative charge, is organized on the PS-b-PAA template via electrostatic interactions under physiological conditions. F-Actin shows a tendency to align along the modified PAA mushroom caps.
引用
收藏
页码:1017 / 1023
页数:7
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