New polyacetylenes, DGAT inhibitors from the roots of Panax ginseng

被引：39
|
作者：
Lee, SW
Kim, K
Rho, MC
Chung, MY
Kim, YH
Lee, S
Lee, HS
Kim, YK
机构：
[1] Korea Res Inst Biosci & Biotechnol, Lab Lipid Metab, Taejon 305333, South Korea
[2] Chungnam Natl Univ, Coll Pharm, Taejon, South Korea
来源：
PLANTA MEDICA | 2004年 / 70卷 / 03期
关键词：
Panax ginseng; Araliaceae; diacylglycerol acyltransferase (DGAT); polyacetylenes; structure elucidation;
D O I：
10.1055/s-2004-815534
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
The petroleum ether extract of Panax ginseng showed a significant inhibition of the diacylglycerol acyltransferase (DGAT) enzyme from rat liver microsomes. Bioactivity-guided fractionation led to the isolation of two new polyacetylenic compounds, (9R,10S)-epoxyheptadecan-4,6-diyn-3-one (1) and 1-methoxy-(9R,10S)-epoxyheptadecan-4,6-diyn-3-one(2). Their chemical structures were elucidated on the basis of spectroscopic evidence and asymmetric synthesis. IC50 values of 9 mug/mL (1) and 32 mug/mL (2) were obtained.
引用
收藏
页码：197 / 200
页数：4
相关论文
共 50 条
  • [41] Transcript expression profiling for adventitious roots of Panax ginseng Meyer
    Subramaniyam, Sathiyamoorthy
    Mathiyalagan, Ramya
    Natarajan, Sathishkumar
    Kim, Yu-Jin
    Jang, Moon-gi
    Park, Jun-Hyung
    Yang, Deok Chun
    GENE, 2014, 546 (01) : 89 - 96
  • [42] Isoconiferoside, a New Phenolic Glucoside from Seeds of Panax ginseng
    Kim, Jeong Ah
    Son, Jeong Hyun
    Yang, Seo Young
    Kim, Young Ho
    MOLECULES, 2011, 16 (08) : 6577 - 6581
  • [43] Antioxidant activities of the oligosaccharides from the roots, flowers and leaves of Panax ginseng CA Meyer
    Jiao, Lili
    Li, Bo
    Wang, Mingzhu
    Liu, Zhen
    Zhang, Xiaoyu
    Liu, Shuying
    CARBOHYDRATE POLYMERS, 2014, 106 : 293 - 298
  • [44] The Potential of Minor Ginsenosides Isolated from the Leaves of Panax ginseng as Inhibitors of Melanogenesis
    Lee, Dae-Young
    Cha, Byeong-Ju
    Lee, Young-Seob
    Kim, Geum-Soog
    Noh, Hyung-Jun
    Kim, Seung-Yu
    Kang, Hee Cheol
    Kim, Jin Hee
    Baek, Nam-In
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2015, 16 (01) : 1677 - 1690
  • [45] ANALYSIS OF GYNZENOSIDES IN THE ROOTS OF PANAX GINSENG INTRODUCED IN THE CENTRAL BOTANICAL GARDEN OF NAS OF BELARUS
    Kochkin, Dmitry, V
    Glagoleva, Elena S.
    Galischev, Boris A.
    Spiridovich, Elena, V
    Nosov, Alexander M.
    Reshetnikov, Vladimir N.
    DOKLADY NATSIONALNOI AKADEMII NAUK BELARUSI, 2018, 62 (04): : 447 - 454
  • [46] Six new dammarane-type triterpene saponins from leaves of Panax ginseng
    Dou, DQ
    Chen, YJ
    Liang, LH
    Pang, FG
    Shimizu, N
    Takeda, T
    CHEMICAL & PHARMACEUTICAL BULLETIN, 2001, 49 (04) : 442 - 446
  • [47] Ginsenine, a new alkaloid from the berry of Panax ginseng C. A.!Meyer
    Wang, J. -Y.
    Li, X. -G.
    Yang, X. -W.
    JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH, 2006, 8 (07) : 605 - 608
  • [48] Gibberellin Signaling Promotes the Secondary Growth of Storage Roots in Panax ginseng
    Hong, Chang Pyo
    Kim, Jinsoo
    Lee, Jinsu
    Yoo, Seung-Il
    Bae, Wonsil
    Geem, Kyoung Rok
    Yu, Jin
    Jang, Inbae
    Jo, Ick Hyun
    Cho, Hyunwoo
    Shim, Donghwan
    Ryu, Hojin
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2021, 22 (16)
  • [49] ANXIOLYTIC ACTIVITY OF PANAX-GINSENG ROOTS - AN EXPERIMENTAL-STUDY
    BHATTACHARYA, SK
    MITRA, SK
    JOURNAL OF ETHNOPHARMACOLOGY, 1991, 34 (01) : 87 - 92
  • [50] Morphological Characterization, Chemical Components, and Biofunctional Activities of Panax ginseng, Panax quinquefolium, and Panax notoginseng Roots: A Comparative Study
    Jee, Hee-Sook
    Chang, Kyung-Hoon
    Park, Se-Ho
    Kim, Kee-Tae
    Paik, Hyun-Dong
    FOOD REVIEWS INTERNATIONAL, 2014, 30 (02) : 91 - 111
12345