New polyacetylenes, DGAT inhibitors from the roots of Panax ginseng

被引：40
作者：
Lee, SW
Kim, K
Rho, MC
Chung, MY
Kim, YH
Lee, S
Lee, HS
Kim, YK
机构：
[1] Korea Res Inst Biosci & Biotechnol, Lab Lipid Metab, Taejon 305333, South Korea
[2] Chungnam Natl Univ, Coll Pharm, Taejon, South Korea
来源：
PLANTA MEDICA | 2004年 / 70卷 / 03期
关键词：
Panax ginseng; Araliaceae; diacylglycerol acyltransferase (DGAT); polyacetylenes; structure elucidation;
D O I：
10.1055/s-2004-815534
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
The petroleum ether extract of Panax ginseng showed a significant inhibition of the diacylglycerol acyltransferase (DGAT) enzyme from rat liver microsomes. Bioactivity-guided fractionation led to the isolation of two new polyacetylenic compounds, (9R,10S)-epoxyheptadecan-4,6-diyn-3-one (1) and 1-methoxy-(9R,10S)-epoxyheptadecan-4,6-diyn-3-one(2). Their chemical structures were elucidated on the basis of spectroscopic evidence and asymmetric synthesis. IC50 values of 9 mug/mL (1) and 32 mug/mL (2) were obtained.
引用
收藏
页码：197 / 200
页数：4
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