Hepatitis C virus infection enhances insulin resistance induced by visceral fat accumulation

被引：29

作者：

Eguchi, Yuichiro ^{[1
]}

Mizuta, Toshihiko ^{[1
]}

Ishibashi, Eriko ^{[1
,2
]}

Kitajima, Yoichiro ^{[1
,2
]}

Oza, Noriko ^{[1
,2
]}

Nakashita, Shunya ^{[2
]}

Hara, Megumi ^{[3
]}

Iwane, Shinji ^{[1
]}

Takahashi, Hirokazu ^{[1
]}

Akiyama, Takumi ^{[1
]}

Ario, Keisuke ^{[1
]}

Kawaguchi, Yasunori ^{[1
]}

Yasutake, Tsutomu ^{[1
]}

Iwakiri, Ryuichi ^{[1
]}

Ozaki, Iwata ^{[1
]}

Hisatomi, Akitaka ^{[1
]}

Eguchi, Takahisa ^{[2
]}

Ono, Naofumi ^{[2
]}

Fujimoto, Kazuma ^{[1
]}

机构：

[1] Saga Med Sch, Dept Internal Med, Saga 8498501, Japan

[2] Eguchi Hosp, Saga, Japan

[3] Saga Med Sch, Dept Prevent Med, Saga 8498501, Japan

来源：

LIVER INTERNATIONAL | 2009年 / 29卷 / 02期

关键词：

abdominal obesity; adipocytokine; central obesity; metabolic syndrome; oxidative stress; NECROSIS FACTOR-ALPHA; BETA-CELL FUNCTION; DIABETES-MELLITUS; LIVER FIBROSIS; RECEPTOR SUBSTRATE-1; TNF-ALPHA; STEATOSIS; HCV; ASSOCIATION; ADIPONECTIN;

D O I：

10.1111/j.1478-3231.2008.01853.x

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

To clarify the impact of visceral obesity on hepatitis C virus (HCV)-infected patients, we examined the relationship between insulin resistance development and visceral fat accumulation. We analyzed 87 HCV-infected patients with mild fibrosis (stage 1 or 2) in comparison with 125 sex- and age-matched patients with non-alcoholic fatty liver disease (NAFLD). The degree of visceral fat area (VFA; cm(2)) at the umbilical level was measured by abdominal computed tomography and divided into two grades: no visceral obesity, VFA < 100 and visceral obesity, VFA >= 100. Insulin resistance was evaluated by homeostasis model assessment of insulin resistance (HOMA-IR) and the quantitative insulin sensitivity check index (QUICKI). Pancreatic beta-cell function was evaluated by homeostasis model assessment of beta-cell function (HOMA-beta). Serum soluble tumour necrosis factor (TNF)-receptors 1 and 2 and adiponectin were measured. Insulin resistance evaluated by HOMA-IR and QUICKI was correlated with visceral fat accumulation, and was higher in HCV patients than in NAFLD patients with visceral obesity. HOMA-beta was higher in HCV patients than in NAFLD patients for each VFA grade. Serum-soluble TNF-receptors 1 and 2 were higher in HCV patients than in NAFLD patients with visceral obesity. Hepatitis C virus infection is a risk factor for development of insulin resistance, particularly in patients with visceral obesity.

引用

页码：213 / 220

页数：8

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