Calcium Dynamics as a Machine for Decoding Signals

被引：210

作者：

Giorgi, Carlotta ^{[1
]}

Danese, Alberto ^{[1
]}

Missiroli, Sonia ^{[1
]}

Patergnani, Simone ^{[1
]}

Pinton, Paolo ^{[1
,2
,3
]}

机构：

[1] Univ Ferrara, Sect Pathol Oncol & Expt Biol, Dept Morphol Surg & Expt Med, Lab Technol Adv Therapies LTTA, Ferrara, Italy

[2] Cecilia Hosp, ES Hlth Sci Fdn, GVM Care & Res, Cotignola, Italy

[3] CNR, Inst Cell Biol & Neurobiol, Monterotondo, Italy

来源：

TRENDS IN CELL BIOLOGY | 2018年 / 28卷 / 04期

关键词：

MITOCHONDRIAL PERMEABILITY TRANSITION; ENDOPLASMIC-RETICULUM; REGULATES APOPTOSIS; NLRP3; INFLAMMASOME; CA2+ TRANSFER; CELL-CYCLE; STROKE; ROLES; ACTIVATION; AUTOPHAGY;

D O I：

10.1016/j.tcb.2018.01.002

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Calcium (Ca2+) is considered one of the most-important biological cations, because it is implicated in cell physiopathology and cell fate through a finely tuned signaling system. In support of this notion, Ca2+ is the primary driver of cell proliferation and cell growth; however, it is also intimately linked to cell death. Functional abnormalities or mutations in proteins that mediate Ca2+ homeostasis usually lead to a plethora of diseases and pathogenic states, including cancer, heart failure, diabetes, and neurodegenerative disease. In this review, we examine recent discoveries in the highly localized nature of Ca2+-dependent signal transduction and its roles in cell fate, inflammasome activation, and synaptic transmission.

引用

收藏

页码：258 / 273

页数：16

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