The influence of external compressive loads, applied along a direction perpendicular to polarization, on fatigue behaviors of multilayer lead zirconate titanate (PZT)-based ceramic actuators was investigated. Under no external mechanical load, a normal fatigue behavior was observed, demonstrating that both switching polarization (P-switching) and remnant polarization (P-r) progressively decreased with increasing switching cycles due to domain pinning by charge point defects. However, an anomalous enhancement in both switching and remnant polarizations was observed upon application of the external compressive loads. After 5x10(6) cycles of polarization switching, P-switching and P-r increase by about 13% and 6% at 40 MPa, respectively, while P-switching and P-r increase by about 11% and 21% at 60 MPa, respectively. The improvement of fatigue resistance can be attributed to non-180 degrees domain switching and suppression of microcracking, triggered by external mechanical loads.