Thinking about RNA? MicroRNAs in the brain

被引：33

作者：

Barbato, Christian ^{[1
]}

Giorgi, Corinna ^{[1
]}

Catalanotto, Caterina ^{[1
,2
]}

Cogoni, Carlo ^{[1
,2
]}

机构：

[1] Fdn EBRI, European Brain Res Inst, I-00143 Rome, Italy

[2] Univ Roma La Sapienza, Dipartimento Biotecnol Cellulari Ematol, Sez Genet Mol, I-00161 Rome, Italy

来源：

MAMMALIAN GENOME | 2008年 / 19卷 / 7-8期

关键词：

D O I：

10.1007/s00335-008-9129-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

MicroRNAs (miRNAs) are a recently discovered class of small RNA molecules implicated in a wide range of diverse gene regulatory mechanisms. Interestingly, numerous miRNAs are expressed in a spatially and temporally controlled manner in the nervous system. This suggests that gene regulation networks based on miRNA activities may be particularly relevant in neurons. Recent studies show the involvement of RNA-mediated gene silencing in neurogenesis, neural differentiation, synaptic plasticity, and neurologic and psychiatric diseases. This review focuses on the roles of miRNAs in the gene regulation of the nervous system.

引用

页码：541 / 551

页数：11

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