Case Definition of Chronic Pulmonary Aspergillosis in Resource-Constrained Settings

被引：112

作者：

Denning, David W. ^{[1
,2
,3
]}

Page, Iain D. ^{[1
,2
]}

Chakaya, Jeremiah ^{[4
]}

Jabeen, Kauser ^{[5
]}

Jude, Cecilia M. ^{[6
]}

Cornet, Muriel ^{[7
]}

Alastruey-Izquierdo, Ana ^{[8
]}

Bongomin, Felix ^{[1
]}

Bowyer, Paul ^{[1
]}

Chakrabarti, Arunaloke ^{[9
]}

Gago, Sara ^{[1
]}

Guto, John ^{[3
]}

Hochhegger, Bruno ^{[10
]}

Hoenigl, Martin ^{[11
,12
,13
]}

Irian, Muhammad ^{[5
]}

Irurhe, Nicholas ^{[14
]}

Izumikawa, Koichi ^{[15
]}

Kirenga, Bruce ^{[16
]}

Manduku, Veronica ^{[4
]}

Moazam, Samihah ^{[2
]}

Oladele, Rita O. ^{[1
,17
]}

Richardson, Malcolm D. ^{[2
]}

Tudela, Juan Luis Rodriguez ^{[3
]}

Rozaliyani, Anna ^{[18
]}

Salzer, Helmut J. F. ^{[19
]}

Sawyer, Richard ^{[2
]}

Simukulwa, Nasilele F. ^{[20
]}

Skrahina, Alena ^{[21
]}

Sriruttan, Charlotte ^{[1
,21
,22
,23
]}

Setianingrum, Findra ^{[1
,18
]}

Ap Wilopo, Bayu ^{[1
,24
]}

Cole, Donald C. ^{[25
]}

Getahun, Haileyesus ^{[26
]}

机构：

[1] Univ Manchester, Manchester, Lancs, England

[2] VVythenshawe Hosp Manchester Univ NHS Fdn Trust, Manchester, Lancs, England

[3] Global Act Fund Fungal Infect, Geneva, Switzerland

[4] Kenya Govt Med Res Ctr, Nairobi, Kenya

[5] Aga Khan Univ, Karachi, Pakistan

[6] Olive View UCLA Med Ctr, 14445 Olive View Dr, Sylmar, CA 91342 USA

[7] Ctr Hosp Univ Grenoble Alpes, Grenoble, France

[8] Inst Salud Carlos III, Madrid, Spain

[9] Postgrad Inst Med Educ & Res, Chandigarh, India

[10] Fed Univ Hlth Sci Porto Alegre, Porto Alegre, RS, Brazil

[11] Univ Calif San Diego, San Diego, CA 92103 USA

[12] Med Univ Graz, Graz, Austria

[13] Ctr Biomarker Res Med, Graz, Austria

[14] Lagos Univ Teaching Hosp, Lagos, Nigeria

[15] Nagasaki Univ, Grad Sch Biomed Sci, Nagasaki, Japan

[16] Mulago Hosp & Makerere Univ, Kampala, Uganda

[17] Univ Lagos, Lagos, Nigeria

[18] Univ Indonesia, Jakarta, Indonesia

[19] Res Ctr Borstel, Borstel, Germany

[20] Royal Liverpool Univ Hosp, Liverpool, Merseyside, England

[21] Republican Sci & Pract Ctr Pulmonol & TB, Minsk, BELARUS

[22] Natl Inst Communicable Dis, Johannesburg, South Africa

[23] Univ Witwatersrand, Johannesburg, South Africa

[24] Univ Padjadjaran, Bandung, Indonesia

[25] Univ Toronto, Toronto, ON, Canada

[26] WHO, Geneva, Switzerland

来源：

EMERGING INFECTIOUS DISEASES | 2018年 / 24卷 / 08期

关键词：

CLINICAL CHARACTERISTICS; ENZYME-IMMUNOASSAY; FUNGAL-INFECTION; IGG ASSAYS; DIAGNOSIS; TUBERCULOSIS; GALACTOMANNAN; VORICONAZOLE; SPECTRUM; SPUTUM;

D O I：

10.3201/eid2408.171312

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Chronic pulmonary aspergillosis (CPA) is a recognized complication of pulmonary tuberculosis (TB). In 2015, the World Health Organization reported 2.2 million new cases of nonbacteriologically confirmed pulmonary TB; some of these patients probably had undiagnosed CPA. In October 2016, the Global Action Fund for Fungal Infections convened an international expert panel to develop a case definition of CPA for resource-constrained settings. This panel defined CPA as illness for >= 3 months and all of the following: 1) weight loss, persistent cough, and/or hemoptysis; 2) chest images showing progressive cavitary infiltrates and/or a fungal ball and/or pericavitary fibrosis or infiltrates or pleural thickening; and 3) a positive Aspergillus IgG assay result or other evidence of Aspergillus infection. The proposed definition will facilitate advancements in research, practice, and policy in lower- and middle-income countries as well as in resource-constrained settings.

引用

页码：E1 / E13

页数：13

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