Ephrin-A1 mRNA is associated with poor prognosis of colorectal cancer

被引：35

作者：

Yamamoto, Hirofumi ^{[1
]}

Tei, Mitsuyoshi ^{[1
]}

Uemura, Mamoru ^{[1
]}

Takemasa, Ichiro ^{[1
]}

Uemura, Yoshio ^{[2
]}

Murata, Kohei ^{[3
]}

Fukunaga, Mutsumi ^{[4
]}

Ohue, Masayuki ^{[5
]}

Ohnishi, Tadashi ^{[6
]}

Ikeda, Kimimasa ^{[7
]}

Kato, Takeshi ^{[8
]}

Okamura, Shu ^{[3
]}

Ikenaga, Masakazu ^{[9
]}

Haraguchi, Naotsugu ^{[1
]}

Nishimura, Junichi ^{[1
]}

Mizushima, Tsunekazu ^{[1
]}

Mimori, Koshi ^{[10
]}

Doki, Yuichiro ^{[1
]}

Mori, Masaki ^{[1
]}

机构：

[1] Osaka Univ, Grad Sch Med, Dept Surg, Suita, Osaka 5650871, Japan

[2] Kinki Cent Hosp, Dept Surg, Kinki, Hyogo, Japan

[3] Suita Municipal Hosp, Dept Surg, Katayama, Osaka, Japan

[4] Sakai City Hosp, Dept Surg, Sakai, Osaka, Japan

[5] Osaka Med Ctr Canc & Cardiovasc Dis, Dept Surg, Osaka, Japan

[6] NTT W Osaka Hosp, Dept Surg, Karasugatsuji, Osaka, Japan

[7] Minoh City Hosp, Dept Surg, Osaka, Japan

[8] Kansai Rosai Hosp, Dept Surg, Amagasaki, Hyogo, Japan

[9] Osaka Natl Hosp, Natl Hosp Org, Dept Surg, Osaka, Japan

[10] Kyushu Univ, Med Inst Bioregulat, Div Mol & Surg Oncol, Dept Mol & Cellular Biol, Ohita, Japan

来源：

INTERNATIONAL JOURNAL OF ONCOLOGY | 2013年 / 42卷 / 02期

关键词：

colorectal cancer; ephrin-A1; hypoxia; prognosis; RECEPTOR TYROSINE KINASE; EPHA RECEPTOR; GROWTH-FACTOR; HYPOXIA; EXPRESSION; CARCINOMA; CYCLOOXYGENASE-2; OVEREXPRESSION; ACTIVATION; MARKER;

D O I：

10.3892/ijo.2012.1750

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We previously studied hypoxic tumor cells from hepatic metastases of colorectal cancer (CRC) and determined several potential prognostic factors, including expression of ephrin-A1 (EFNA1), which was highly induced by hypoxia. Here, we further evaluated the prognostic impact of EFNA1 expression. Samples from a total of 366 CRC patients from 11 institutes were analyzed by either microarray (n=220) or quantitative reverse-transcriptase polymerase chain reaction (n=146). EFNA1 was an independent prognostic factor for CRC (p<0.05). In vitro assays revealed that loss of EFNA1 following siRNA treatment was associated with reduced proliferative activity and decreased invasion and migration of CRC cell lines. EFNA1 expression is a useful marker for predicting high risk of relapse and cancer-related death in patients who have undergone curative resection for CRC.

引用

页码：549 / 555

页数：7

共 34 条

[1] Expression of EphA2 and ephrin A-1 in carcinoma of the urinary bladder [J].

Abraham, S ;

Knapp, DW ;

Cheng, L ;

Snyder, PW ;

Mittal, SK ;

Bangari, DS ;

Kinch, M ;

Wu, L ;

Dhariwal, J ;

Mohammed, SI .

CLINICAL CANCER RESEARCH, 2006, 12 (02) :353-360

[2] B61 IS A LIGAND FOR THE ECK RECEPTOR PROTEIN-TYROSINE KINASE [J].

BARTLEY, TD ;

HUNT, RW ;

WELCHER, AA ;

BOYLE, WJ ;

PARKER, VP ;

LINDBERG, RA ;

LU, HS ;

COLOMBERO, AM ;

ELLIOTT, RL ;

GUTHRIE, BA ;

HOLST, PL ;

SKRINE, JD ;

TOSO, RJ ;

ZHANG, M ;

FERNANDEZ, E ;

TRAIL, G ;

VARNUM, B ;

YARDEN, Y ;

HUNTER, T ;

FOX, GM .

NATURE, 1994, 368 (6471) :558-560

[3] Soluble Eph A receptors inhibit tumor angiogenesis and progression in vivo [J].

Brantley, DM ;

Cheng, N ;

Thompson, EJ ;

Lin, Q ;

Brekken, RA ;

Thorpe, PE ;

Muraoka, RS ;

Cerretti, DP ;

Pozzi, A ;

Jackson, D ;

Lin, C ;

Chen, J .

ONCOGENE, 2002, 21 (46) :7011-7026

[4] Ephrin-A1 facilitates mammary tumor metastasis through an angiogenesis-dependent mechanism mediated by EphA receptor and vascular endothelial growth factor in mice [J].

Brantley-Sieders, Dana M. ;

Fang, Wei Bin ;

Hwang, Yoonha ;

Hicks, Donna ;

Chen, Jin .

CANCER RESEARCH, 2006, 66 (21) :10315-10324

[5] CA IX is an independent prognostic marker in premenopausal breast cancer patients with one to three positive lymph nodes and a putative marker of radiation resistance [J].

Brennan, Donal J. ;

Jirstrom, Karin ;

Kronblad, Asa ;

Millikan, Robert C. ;

Landberg, Goran ;

Duffy, Michael J. ;

Ryden, Lisa ;

Gallagher, William M. ;

O'Brien, Sallyann L. .

CLINICAL CANCER RESEARCH, 2006, 12 (21) :6421-6431

[6]

Cheng N, 2002, MOL CANCER RES, V1, P2

[7] EphrinA1 inactivates integrin-mediated vascular smooth muscle cell spreading via the Rac/PAK pathway [J].

Deroanne, C ;

Vouret-Craviari, V ;

Wang, BC ;

Pouysségur, J .

JOURNAL OF CELL SCIENCE, 2003, 116 (07) :1367-1376

[8] Hypoxia - A key regulatory factor in tumour growth [J].

Harris, AL .

NATURE REVIEWS CANCER, 2002, 2 (01) :38-47

[9] Differential expression of cyclooxygenase-2 (COX-2) in human bile duct epithelial cells and bile duct neoplasm [J].

Hayashi, N ;

Yamamoto, H ;

Hiraoka, N ;

Dono, K ;

Ito, Y ;

Okami, J ;

Kondo, M ;

Nagano, H ;

Umeshita, K ;

Sakon, M ;

Matsuura, N ;

Nakamori, S ;

Monden, M .

HEPATOLOGY, 2001, 34 (04) :638-650

[10]

Holm Ruth, 2008, Int J Med Sci, V5, P121

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