Detecting diffuse axonal injury in rat brainstems by diffusion tensor imaging and AQP4 expression

被引：1

作者：

Zheng, Wenbin ^{[1
]}

Ma, Chunlin ^{[2
]}

Kong, Lingmei ^{[1
]}

Chen, Xiran ^{[1
]}

Fan, Wenyao ^{[1
]}

机构：

[1] Shantou Univ, Dept Radiol, Affiliated Hosp 2, Coll Med, Shantou, Peoples R China

[2] Kiang Wu Hosp, Dept Radiol, Macau, Peoples R China

来源：

BIO-MEDICAL MATERIALS AND ENGINEERING | 2015年 / 26卷

关键词：

Diffusion axonal injury; brain edema; AQP4; diffusion tensor imaging; apparent diffusion coefficient (ADC); fractional anisotropy (FA); AQUAPORIN-4; EDEMA; MILD;

D O I：

10.3233/BME-151413

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

This study investigated the correlation between AQP4 expression and DTI in rat brainstems after diffuse axonal injuries (DAI). Forty rats were imaged before injury and reimaged at 3, 6, 12, 24 and 72 h post-injury. A control group of 8 rats was imaged and sacrificed for histology but not injured. After brain injury, AQP4 expression and ADC values in the brainstems increased gradually, reaching peak values at 24 h and 12 h, respectively. FA values decreased within 72 h. There was a negative correlation between ADC values and brainstem AQP4 expression at 12 h, and a positive correlation at 24 h or 72 h (P < 0.01), respectively. Changes in the ADC and FA values in the brainstems indicated brain edema and severe axonal injuries. The correlations between AQP4 expression and time-dependent ADC values aid in understanding brain edema development after DAI.

引用

页码：S1169 / S1175

页数：7

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