Compositional and toxicological analysis of a GM potato line with reduced α-solanine content - A 90-day feeding study in the Syrian Golden hamster

被引：12

作者：

Langkilde, Soren ^{[1
]}

Schroder, Malene ^{[1
]}

Frank, Thomas ^{[2
]}

Shepherd, Louise V. T. ^{[3
]}

Conner, Sean ^{[3
]}

Davies, Howard V. ^{[3
]}

Meyer, Otto ^{[1
]}

Danier, Juergen ^{[4
]}

Rychlik, Michael ^{[5
]}

Belknap, William R. ^{[6
]}

McCue, Kent F. ^{[6
]}

Engel, Karl-Heinz ^{[2
]}

Stewart, Derek ^{[3
]}

Knudsen, Ib ^{[1
]}

Poulsen, Morten ^{[1
]}

机构：

[1] Tech Univ Denmark, Natl Food Inst, DK-2860 Soborg, Denmark

[2] Tech Univ Munich, Lehrstuhl Algemeine Lebensmitteltechnol, D-85350 Freising Weihenstephan, Germany

[3] James Hutton Inst, Dundee DD2 5DA, Scotland

[4] Tech Univ Munich, Res Ctr Nutr & Food Sci, D-85350 Freising Weihenstephan, Germany

[5] Tech Univ Munich, Chair Analyt Food Chem, D-85350 Freising Weihenstephan, Germany

[6] ARS, USDA, Crop Improvement & Utilizat Res Unit, Western Reg Res Ctr, Albany, CA USA

来源：

REGULATORY TOXICOLOGY AND PHARMACOLOGY | 2012年 / 64卷 / 01期

关键词：

Glycoalkaloid; alpha-Solanine; alpha-Chaconine; GM; Potato; Acetylcholinesterase (AChE); Hamster; Toxicity; Compositional analyses; SYNERGISTIC INTERACTION; GLYCOALKALOIDS; CHACONINE; TOXICITY; PLANT; METABOLITES; CONSUMPTION; TUBEROSUM; SAFETY; ASSAY;

D O I：

10.1016/j.yrtph.2012.06.018

中图分类号：

DF [法律]; D9 [法律]; R [医药、卫生];

学科分类号：

0301 ; 10 ;

摘要：

Steroidal glycoalkaloids (GAs) are toxins, produced by plants of the Solanaceae family. The potato plant (Solanum tuberosum L.) and its tubers predominantly contain the two GAs alpha-chaconine and alpha-solanine. These compounds are believed to act in synergy, and the degree of toxicity may therefore depend on their ratio in the potato. To determine the influence of alpha-solanine: alpha-chaconine ratio in potatoes on toxicity, a GM potato line (SGT 9-2) with reduced alpha-solanine content, and the parental control line (Desiree wildtype) having a traditional a-solanine: alpha-chaconine ratio were (1) studied for compositional similarity by analysing for a range of potato constituents, and (2) used in a 90-day feeding trial with the Syrian Golden hamster to study differential toxicity. The animal feeding study used diets with up to 60% freeze-dried potato powder from either line. Whilst data indicated some compositional differences between the GM line and its wildtype control these did not raise concerns related to nutritional value or safety. Results of the feeding trials showed a low number of significant differences between potato lines with different alpha-solanine: alpha-chaconine ratio but none were considered to raise safety concerns with regard to human (or animal) consumption. (C) 2012 Elsevier Inc. All rights reserved.

引用

页码：177 / 185

页数：9

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