Low-density lipoprotein, its susceptibility to oxidation and the role of lipoprotein-associated phospholipase A2 and carboxyl ester lipase lipases in atherosclerotic plaque formation

被引：36

作者：

Burchardt, Pawel ^{[1
]}

Zurawski, Jakub ^{[2
]}

Zuchowski, Bartosz ^{[3
]}

Kubacki, Tomasz ^{[2
]}

Murawa, Dawid ^{[4
]}

Wiktorowicz, Krzysztof ^{[2
]}

Wysocki, Henryk ^{[3
]}

机构：

[1] Poznan Univ Med Sci, Dept Internal Med, Div Cardiol Intens Therapy, PL-60355 Poznan, Poland

[2] Poznan Univ Med Sci, Dept Biol & Environm Sci, PL-60355 Poznan, Poland

[3] Poznan Univ Med Sci, Div Cardiol Intens Therapy, PL-60355 Poznan, Poland

[4] Wielkopolska Canc Ctr, Dept Surg Oncol & Gen Surg 1, Poznan, Poland

来源：

ARCHIVES OF MEDICAL SCIENCE | 2013年 / 9卷 / 01期

关键词：

carboxyl ester lipase; lipoprotein-associated phospholipase A(2); atherosclerosis; lipoproteins; ACTIVATING-FACTOR-ACETYLHYDROLASE; NF-KAPPA-B; APOLIPOPROTEIN-B; OXIDIZED LDL; DISEASE; DEFICIENCY; METABOLISM; ABSORPTION; GUIDELINES; SECRETION;

D O I：

10.5114/aoms.2013.33176

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

An increased level of low-density lipoprotein (LDL) is a very well established risk factor of coronary artery disease (CAD). Unoxidized LDL is an inert transport vehicle of cholesterol and other lipids in the body and is thought to be atherogenic. Recently it has been appreciated that oxidized products of LDL are responsible for plaque formation properties previously attributed to the intact particle. The goal of this article is to review the recent understanding of the LDL oxidation pathway. The role of oxidized products and key enzymes (lipoprotein-assodated phospholipase A(2) and carboxyl ester lipase) are also extensively discussed in the context of clinical conditions.

引用

页码：151 / 158

页数：8

共 57 条

[1] Endothelial scavenger receptors [J].

Adachi, Hideki ;

Tsujimoto, Masafumi .

PROGRESS IN LIPID RESEARCH, 2006, 45 (05) :379-404

[2] High-density lipoproteins and cardiovascular disease: 2010 update [J].

Alwaili, Khalid ;

Awan, Zuhier ;

Alshahrani, Ali ;

Genest, Jacques .

EXPERT REVIEW OF CARDIOVASCULAR THERAPY, 2010, 8 (03) :413-423

[3] Direct, real-time measurement of shear stress-induced nitric oxide produced from endothelial cells in vitro [J].

Andrews, Allison M. ;

Jaron, Dov ;

Buerk, Donald G. ;

Kirby, Patrick L. ;

Barbee, Kenneth A. .

NITRIC OXIDE-BIOLOGY AND CHEMISTRY, 2010, 23 (04) :335-342

[4] NF-κB, Inflammation, and Metabolic Disease [J].

Baker, Rebecca G. ;

Hayden, Matthew S. ;

Ghosh, Sankar .

CELL METABOLISM, 2011, 13 (01) :11-22

[5]

Brkic S, 2010, MED SCI MONITOR, V16, pCR628

[6] PLASMA-CHOLESTEROL ESTERASE LEVEL IS A DETERMINANT FOR AN ATHEROGENIC LIPOPROTEIN PROFILE IN NORMOLIPIDEMIC HUMAN-SUBJECTS [J].

BRODTEPPLEY, J ;

WHITE, P ;

JENKINS, S ;

HUI, DY .

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, 1995, 1272 (02) :69-72

[7] THE SCAVENGER CELL PATHWAY FOR LIPOPROTEIN DEGRADATION - SPECIFICITY OF THE BINDING-SITE THAT MEDIATES THE UPTAKE OF NEGATIVELY-CHARGED LDL BY MACROPHAGES [J].

BROWN, MS ;

BASU, SK ;

FALCK, JR ;

HO, YK ;

GOLDSTEIN, JL .

JOURNAL OF SUPRAMOLECULAR STRUCTURE, 1980, 13 (01) :67-81

[8] Carboxyl ester lipase cofractionates with scavenger receptor BI in hepatocyte lipid rafts and enhances selective uptake and hydrolysis of cholesteryl esters from HDL3 [J].

Camarota, LM ;

Chapman, JM ;

Hui, DY ;

Howles, PN .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (26) :27599-27606

[9] NF-κB:: pivotal mediator or innocent bystander in atherogenesis? [J].

Collins, T ;

Cybulsky, MI .

JOURNAL OF CLINICAL INVESTIGATION, 2001, 107 (03) :255-264

[10]

Colonna VDG, 2009, MED SCI MONITOR, V15, pRA91

← 1 2 3 4 5 6 →