Clonal Hematopoiesis and Evolution to Hematopoietic Malignancies

被引：347

作者：

Bowman, Robert L. ^{[1
,2
]}

Busque, Lambert ^{[4
]}

Levine, Ross L. ^{[1
,2
,3
]}

机构：

[1] Mem Sloan Kettering Canc Ctr, Human Oncol & Pathogenesis Program, 1275 York Ave, New York, NY 10021 USA

[2] Mem Sloan Kettering Canc Ctr, Ctr Epigenet Res, 1275 York Ave, New York, NY 10021 USA

[3] Mem Sloan Kettering Canc Ctr, Dept Med, Leukemia Serv, 1275 York Ave, New York, NY 10021 USA

[4] Univ Montreal, Hop Maisonneuve Rosemont, Res Ctr, Montreal, PQ, Canada

来源：

CELL STEM CELL | 2018年 / 22卷 / 02期

关键词：

ACUTE MYELOID-LEUKEMIA; STEM-CELL TRANSPLANTATION; TET2 LOSS LEADS; SELF-RENEWAL; SOMATIC MUTATIONS; DNA-DAMAGE; APLASTIC-ANEMIA; MYELOPROLIFERATIVE NEOPLASMS; STEM/PROGENITOR CELLS; EPIGENETIC CONTROL;

D O I：

10.1016/j.stem.2018.01.011

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Clonal hematopoiesis (CH) broadly describes the expansion of a clonal population of blood cells with one or more somatic mutations. Individuals with CH are at greater risk for hematological malignancies, cardiovascular disease, and increased mortality from non-hematological cancers. Understanding the causes of CH and how these mutant cells interact with cells of other tissues will provide critical insights into preleukemic development, stem cell biology, host-immune interactions, and cancer evolution. Here we discuss the clinical manifestations of CH, mechanisms contributing to its development, the role of CH in clonal evolution toward leukemia, and the contribution of CH to non-hematological disease states.

引用

页码：157 / 170

页数：14

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