Quantitative OCT angiography of optic nerve head blood flow

被引:384
作者
Jia, Yali [1 ]
Morrison, John C. [1 ]
Tokayer, Jason [2 ]
Tan, Ou [1 ]
Lombardi, Lorinna [1 ]
Baumann, Bernhard [3 ,4 ]
Lu, Chen D. [3 ,4 ]
Choi, WooJhon [3 ,4 ]
Fujimoto, James G. [3 ,4 ]
Huang, David [1 ]
机构
[1] Oregon Hlth & Sci Univ, Casey Eye Inst, Portland, OR 97239 USA
[2] Univ So Calif, Dept Elect Engn, Los Angeles, CA 90089 USA
[3] MIT, Dept Elect Engn & Comp Sci, Cambridge, MA 02139 USA
[4] MIT, Elect Res Lab, Cambridge, MA 02139 USA
关键词
OPEN-ANGLE GLAUCOMA; LASER-DOPPLER FLOWMETRY; COHERENCE TOMOGRAPHY; SWEPT-SOURCE; MICROVASCULATURE; HEMORHEOLOGY; FLUORESCEIN; PREVALENCE; PERFUSION; RETINA;
D O I
10.1364/BOE.3.003127
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
Optic nerve head (ONH) blood flow may be associated with glaucoma development. A reliable method to quantify ONH blood flow could provide insight into the vascular component of glaucoma pathophysiology. Using ultrahigh-speed optical coherence tomography (OCT), we developed a new 3D angiography algorithm called split-spectrum amplitude-decorrelation angiography (SSADA) for imaging ONH microcirculation. In this study, a method to quantify SSADA results was developed and used to detect ONH perfusion changes in early glaucoma. En face maximum projection was used to obtain 2D disc angiograms, from which the average decorrelation values (flow index) and the percentage area occupied by vessels (vessel density) were computed from the optic disc and a selected region within it. Preperimetric glaucoma patients had significant reductions of ONH perfusion compared to normals. This pilot study indicates OCT angiography can detect the abnormalities of ONH perfusion and has the potential to reveal the ONH blood flow mechanism related to glaucoma. (C) 2012 Optical Society of America
引用
收藏
页码:3127 / 3137
页数:11
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