Relationship between Structure and Antiproliferative Activity of Polymethoxyflavones towards HL60 Cells

被引：0

作者：

Kawaii, Satoru ^{[1
]}

Ikuina, Tomoyasu

Hikima, Takeshi

Tokiwano, Tetsuo ^{[2
]}

Yoshizawa, Yuko ^{[2
]}

机构：

[1] Tokyo Denki Univ, Fac Sci & Engn, Bioorgan Chem Lab, Hatoyama, Saitama 3500394, Japan

[2] Akita Prefectural Univ, Bioorgan Chem Lab, Akita, Japan

来源：

ANTICANCER RESEARCH | 2012年 / 32卷 / 12期

关键词：

Polymethoxylated flavone; antiproliferative activity; HL60; cells; structure and activity relationship; FLAVONOIDS; NOBILETIN; CANCER;

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

As part of our continuing investigation of polymethoxyflavone (PMF) derivatives as potential anticancer substances, a series of PMF derivatives was synthesized. The synthesized compounds were evaluated for cytotoxicity against the promyelocytic leukemic HL60 cell line, and structure activity relationship correlations were investigated along with previously isolated PMFs from the peel of king orange (Citrus nobilis). 7,3'-Dimethoxyflavone demonstrated the most potent activity among the synthetic PMFs. Consideration of correlation between the methoxylation pattern and antiproliferative activity revealed the importance of the 3'-methoxyl group and the higher degree of methoxylation on the A-ring moiety of PMFs.

引用

页码：5239 / 5244

页数：6

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