The adaptive immune response in celiac disease

被引：41

作者：

Qiao, Shuo-Wang ^{[1
,2
]}

Iversen, Rasmus ^{[1
,2
]}

Raki, Melinda ^{[1
,2
,3
]}

Sollid, Ludvig M. ^{[1
,2
]}

机构：

[1] Univ Oslo, Oslo Univ Hosp, Rikshosp, Dept Immunol, N-0027 Oslo, Norway

[2] Univ Oslo, Oslo Univ Hosp, Rikshosp, Ctr Immune Regulat, N-0027 Oslo, Norway

[3] Oslo Univ Hosp, Dept Pathol, Rikshosp, N-0027 Oslo, Norway

来源：

SEMINARS IN IMMUNOPATHOLOGY | 2012年 / 34卷 / 04期

关键词：

Celiac disease; Gluten; Tcells; B cells; Antigen-presenting cells; ANTITISSUE TRANSGLUTAMINASE ANTIBODIES; T-CELL EPITOPE; PLASMACYTOID DENDRITIC CELLS; INFLAMMATORY-BOWEL-DISEASE; PEPTIDE BINDING CHARACTERISTICS; DEAMIDATED GLIADIN PEPTIDES; LINKED-IMMUNOSORBENT-ASSAY; SMALL-INTESTINAL MUCOSA; IMMUNOGLOBULIN-G IGG; CHRONIC HEPATITIS-C;

D O I：

10.1007/s00281-012-0314-z

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Compared to other human leukocyte antigen (HLA)-associated diseases such as type 1 diabetes, multiple sclerosis, and rheumatoid arthritis, fundamental aspects of the pathogenesis in celiac disease are relatively well understood. This is mostly because the causative antigen in celiac disease-cereal gluten proteins-is known and the culprit HLA molecules are well defined. This has facilitated the dissection of the disease-relevant CD4+ T cells interacting with the disease-associated HLA molecules. In addition, celiac disease has distinct antibody responses to gluten and the autoantigen transglutaminase 2, which give strong handles to understand all sides of the adaptive immune response leading to disease. Here we review recent developments in the understanding of the role of T cells, B cells, and antigen-presenting cells in the pathogenic immune response of this instructive disorder.

引用

页码：523 / 540

页数：18