Effects of pretransplant sarcopenia and sequential changes in sarcopenic parameters after living donor liver transplantation

被引:81
作者
Kaido, Toshimi [1 ]
Tamai, Yumiko [2 ]
Hamaguchi, Yuhei [1 ]
Okumura, Shinya [1 ]
Kobayashi, Atsushi [1 ]
Shirai, Hisaya [1 ]
Yagi, Shintaro [1 ]
Kamo, Naoko [1 ]
Hammad, Ahmed [1 ,3 ]
Inagaki, Nobuya [2 ,4 ]
Uemoto, Shinji [1 ]
机构
[1] Kyoto Univ, Grad Sch Med, Div Hepatobiliary Pancreat & Transplant Surg, Dept Surg, Kyoto, Japan
[2] Kyoto Univ Hosp, Dept Metab & Clin Nutr, Kyoto, Japan
[3] Mansoura Univ, Dept Surg, Mansoura, Egypt
[4] Kyoto Univ, Grad Sch Med, Dept Diabet Endocrinol & Nutr, Kyoto, Japan
关键词
Sarcopenia; Liver transplantation; Skeletal muscle mass; Grip strength; Nutrition; INFECTION; CONSENSUS; OUTCOMES; SURGERY; LESSONS; IMPACT; GRAFT;
D O I
10.1016/j.nut.2016.07.002
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Objective: sarcopenia is characterized by muscle mass depletion and decrease in muscle power or physical activity. We previously reported that low skeletal muscle mass (SMM) is closely involved with posttransplant mortality in patients undergoing living donor liver transplantation (LDLT). The aim of this study was to prospectively investigate the effects of pretransplant sarcopenia on survival and examine sequential changes in sarcopenic parameters after LDLT. Methods: Sarcopenia was defined by measuring SMM using a multifrequency body composition analyzer and assessing grip strength (GS) in 72 adults who underwent LDLT at Kyoto University Hospital between January 2013 and October 2015. The effects of pretransplant sarcopenia on short-term survival and sequential changes in SMM and GS were prospectively analyzed. Results: Of 72 patients, 10 (14%) were defined as having pretransplant sarcopenia. Overall survival rates were significantly lower in patients with sarcopenia (n = 10) than those without sarcopenia (n = 62; P < 0.001). SMM worsened after LDLT and did not return to preoperative levels until 1 y after LDLT. In contrast, GS returned to preoperative levels at 6 mo after LDLT, following sharp decrease at I mo after LDLT. Conclusions: This prospective study confirmed that pretransplant sarcopenia is closely associated with short-term survival after LDLT and that GS recovers before SMM. (C) 2016 Elsevier Inc. All rights reserved.
引用
收藏
页码:195 / 198
页数:4
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