Hypoxia-inducible factor as a physiological regulator

被引：136
|
作者：
Maxwell, PH [1 ]
机构：
[1] Univ London Imperial Coll Sci Technol & Med, London W12 0NN, England
来源：
EXPERIMENTAL PHYSIOLOGY | 2005年 / 90卷 / 06期
基金：
英国惠康基金;
关键词：
D O I：
10.1113/expphysiol.2005.030924
中图分类号：
Q4 [生理学];
学科分类号：
071003 ;
摘要：
Hypoxia-inducible factor (HIF) is a transcription complex which responds to changes in oxygen, providing cells with a master regulator that coordinates changes in gene transcription. HIF operates in all mammalian cell types and is ancient in evolutionary terms, being conserved in C. elegans and D. melanogaster. This review summarizes recent insights into the molecular events that link reduced oxygenation to HIF activation and emerging insights into the extensive role of HIF in a broad range of physiological processes.
引用
收藏
页码：791 / 797
页数：7
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