S-adenosyl-L-homocysteine hydrolase is sequestered into actin rods in Dictyostelium discoideum spores

被引：9
作者：
Kishi, Y
Sugo, T
Mahadeo, D
Cotter, D
Sameshima, M
机构：
[1] Tokyo Metropolitan Org Med Res, Tokyo Metropolitan Inst Med Sci, Ctr Electron Microscopy, Bunkyo Ku, Tokyo 1138613, Japan
[2] Jichi Med Sch, Ctr Mol Med, Div Cell & Mol Med, Minami Kawachi, Tochigi 3290498, Japan
[3] Univ Windsor, Dept Biol Sci, Windsor, ON N9B 3P4, Canada
来源：
FEBS LETTERS | 2001年 / 508卷 / 03期
关键词：
S-adenosyl-L-homocysteine hydrolase; actin; antivirus; Dictyostelium;
D O I：
10.1016/S0014-5793(01)03105-2
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Here we show evidence that S-adenosyl-L-homocysteine hydrolase (SAHH) is linked to the actin cytoskeleton. Actin rods formed in Dictyostelium discoideum spores during the final stage of development are structurally composed of novel bundles of actin filaments. SAHH only accumulates with actin at this stage of development in the life cycle of D. discoideum. Recently SAHH is believed to be a target for antiviral chemotherapy and the suppression of T cells. Our finding may contribute to designing novel antiviral and immunosuppressive drugs. (C) 2001 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.
引用
收藏
页码：433 / 437
页数：5
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