S-adenosyl-L-homocysteine hydrolase is sequestered into actin rods in Dictyostelium discoideum spores

被引：9

作者：

Kishi, Y

Sugo, T

Mahadeo, D

Cotter, D

Sameshima, M

机构：

[1] Tokyo Metropolitan Org Med Res, Tokyo Metropolitan Inst Med Sci, Ctr Electron Microscopy, Bunkyo Ku, Tokyo 1138613, Japan

[2] Jichi Med Sch, Ctr Mol Med, Div Cell & Mol Med, Minami Kawachi, Tochigi 3290498, Japan

[3] Univ Windsor, Dept Biol Sci, Windsor, ON N9B 3P4, Canada

来源：

FEBS LETTERS | 2001年 / 508卷 / 03期

关键词：

S-adenosyl-L-homocysteine hydrolase; actin; antivirus; Dictyostelium;

D O I：

10.1016/S0014-5793(01)03105-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Here we show evidence that S-adenosyl-L-homocysteine hydrolase (SAHH) is linked to the actin cytoskeleton. Actin rods formed in Dictyostelium discoideum spores during the final stage of development are structurally composed of novel bundles of actin filaments. SAHH only accumulates with actin at this stage of development in the life cycle of D. discoideum. Recently SAHH is believed to be a target for antiviral chemotherapy and the suppression of T cells. Our finding may contribute to designing novel antiviral and immunosuppressive drugs. (C) 2001 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.

引用

页码：433 / 437

页数：5

共 42 条

[21] RNA interference of a putative S-adenosyl-L-homocysteine hydrolase gene affects larval performance in Leptinotarsa decemlineata (Say) [J].

Zhou, Li-Tao ;

Jia, Shuang ;

Wan, Pin-Jun ;

Kong, Ye ;

Guo, Wen-Chao ;

Ahmat, Tursun ;

Li, Guo-Qing .

JOURNAL OF INSECT PHYSIOLOGY, 2013, 59 (10) :1049-1056

[22] The active center and beyond: towards new selective inhibitors of S-adenosyl-L-homocysteine hydrolase from Pseudomonas aeruginosa [J].

Brzezinski, Krzysztof ;

Czyrko, Justyna ;

Imierska, Monika ;

Olszynska, Patrycja .

ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES, 2015, 71 :S210-S210

[23] Morphological changes and hypomethylation of DNA in transgenic tobacco expressing antisense RNA of the S-adenosyl-l-homocysteine hydrolase gene [J].

Hideo Tanaka ;

Chikara Masuta ;

Kyoko Uehara ;

Jiro Kataoka ;

Akira Koiwai ;

Masana Noma .

Plant Molecular Biology, 1997, 35 :981-986

[24] An enzyme captured in two conformational states: crystal structure of S-adenosyl-L-homocysteine hydrolase from Bradyrhizobium elkanii [J].

Manszewski, Tomasz ;

Singh, Kriti ;

Imiolczyk, Barbara ;

Jaskolski, Mariusz .

ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY, 2015, 71 :2422-2432

[25] Open-chain carbocyclic analogs of adenosine with dihalovinyl unit as potential inhibitors of S-adenosyl-L-homocysteine hydrolase [J].

Lewandowska, E ;

Lalama, J ;

Yuan, CS ;

Wnuk, SF .

NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS, 2003, 22 (09) :1747-1755

[26] Real-time monitoring of S-adenosyl-L-homocysteine hydrolase using a chemodosimetric fluorescence "turn-on" sensor [J].

Lee, Kyung-Sik ;

Lee, Seung Hwan ;

Oh, Jinrok ;

Shin, Ik-Soo ;

Park, Tai Hyun ;

Hong, Jong-In .

SENSORS AND ACTUATORS B-CHEMICAL, 2013, 185 :663-668

[27] Morphological changes and hypomethylation of DNA in transgenic tobacco expressing antisense RNA of the S-adenosyl-L-homocysteine hydrolase gene [J].

Tanaka, H ;

Masuta, C ;

Uehara, K ;

Kataoka, J ;

Koiwai, A ;

Noma, M .

PLANT MOLECULAR BIOLOGY, 1997, 35 (06) :981-986

[28] Localization of a cytokinin-binding protein CBP57/S-adenosyl-L-homocysteine hydrolase in a tobacco root [J].

Mitsui, S ;

Wakasugi, T ;

Hanano, S ;

Sugiura, M .

JOURNAL OF PLANT PHYSIOLOGY, 1997, 150 (06) :752-754

[29] The S-adenosyl-L-homocysteine hydrolase of Drosophila melanogaster: Identification, deduced amino acid sequence and cytological localization of the structural gene [J].

Caggese, C ;

Ragone, G ;

Barsanti, P ;

Moschetti, R ;

Messina, A ;

Massari, S ;

Caizzi, R .

MOLECULAR AND GENERAL GENETICS, 1997, 253 (04) :492-498

[30] Synthesis of 2-modified aristeromycins and their analogs as potent inhibitors against Plasmodium falciparum S-adenosyl-L-homocysteine hydrolase [J].

Ando, Takayuki ;

Iwata, Masafumi ;

Zulfiqar, Fazila ;

Miyamoto, Tatsuya ;

Nakanishi, Masayuki ;

Kitade, Yukio .

BIOORGANIC & MEDICINAL CHEMISTRY, 2008, 16 (07) :3809-3815

← 1 2 3 4 5 →