S-adenosyl-L-homocysteine hydrolase is sequestered into actin rods in Dictyostelium discoideum spores

被引：9
作者：
Kishi, Y
Sugo, T
Mahadeo, D
Cotter, D
Sameshima, M
机构：
[1] Tokyo Metropolitan Org Med Res, Tokyo Metropolitan Inst Med Sci, Ctr Electron Microscopy, Bunkyo Ku, Tokyo 1138613, Japan
[2] Jichi Med Sch, Ctr Mol Med, Div Cell & Mol Med, Minami Kawachi, Tochigi 3290498, Japan
[3] Univ Windsor, Dept Biol Sci, Windsor, ON N9B 3P4, Canada
来源：
FEBS LETTERS | 2001年 / 508卷 / 03期
关键词：
S-adenosyl-L-homocysteine hydrolase; actin; antivirus; Dictyostelium;
D O I：
10.1016/S0014-5793(01)03105-2
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Here we show evidence that S-adenosyl-L-homocysteine hydrolase (SAHH) is linked to the actin cytoskeleton. Actin rods formed in Dictyostelium discoideum spores during the final stage of development are structurally composed of novel bundles of actin filaments. SAHH only accumulates with actin at this stage of development in the life cycle of D. discoideum. Recently SAHH is believed to be a target for antiviral chemotherapy and the suppression of T cells. Our finding may contribute to designing novel antiviral and immunosuppressive drugs. (C) 2001 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.
引用
收藏
页码：433 / 437
页数：5
相关论文
共 41 条
  • [1] Colocalization of actin and S-adenosyl-L-homocysteine hydrolase in response to the osmotic stress in Dictyostelium discoideum cells
    Yamada, Yohko
    Sameshima, Masazumi
    CELL STRUCTURE AND FUNCTION, 2004, 29 : 39 - 39
  • [2] THE GENE AND PSEUDOGENES OF RAT S-ADENOSYL-L-HOMOCYSTEINE HYDROLASE
    MERTA, A
    AKSAMIT, RR
    KASIR, J
    CANTONI, GL
    EUROPEAN JOURNAL OF BIOCHEMISTRY, 1995, 229 (02): : 575 - 582
  • [3] The formation of actin rods composed of actin tubules in Dictyostelium discoideum spores
    Sameshima, M
    Kishi, Y
    Osumi, M
    Minamikawa-Tachino, R
    Mahadeo, D
    Cotter, DA
    JOURNAL OF STRUCTURAL BIOLOGY, 2001, 136 (01) : 7 - 19
  • [4] Binding of Cu2+ to S-adenosyl-L-homocysteine hydrolase
    Li, YJ
    Chen, JJ
    Liu, J
    Yang, XD
    Wang, K
    JOURNAL OF INORGANIC BIOCHEMISTRY, 2004, 98 (06) : 977 - 983
  • [5] NOVEL ACTIN RODS APPEARED IN SPORES OF DICTYOSTELIUM-DISCOIDEUM
    SAMESHIMA, M
    CHIJIIWA, Y
    KISHI, Y
    HASHIMOTO, Y
    CELL STRUCTURE AND FUNCTION, 1994, 19 (04) : 189 - 194
  • [6] S-adenosyl-L-homocysteine hydrolase and methylation disorders: Yeast as a model system
    Tehlivets, Oksana
    Malanovic, Nermina
    Visram, Myriam
    Paykov-Keller, Tea
    Keller, Walter
    BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, 2013, 1832 (01): : 204 - 215
  • [7] S-Adenosyl-L-Homocysteine Hydrolase Inhibition by a Synthetic Nicotinamide Cofactor Biomimetic
    Kailing, Lyn L.
    Bertinetti, Daniela
    Paul, Caroline E.
    Manszewski, Tomasz
    Jaskolski, Mariusz
    Herberg, Friedrich W.
    Pavlidis, Ioannis V.
    FRONTIERS IN MICROBIOLOGY, 2018, 9
  • [8] Inhibitory effect of Epimedium extract on S-adenosyl-L-homocysteine hydrolase and biomethylation
    Zhang, XY
    Li, YJ
    Yang, XD
    Wang, K
    Ni, JZ
    Qu, XG
    LIFE SCIENCES, 2005, 78 (02) : 180 - 186
  • [9] Design and Synthesis of Amide Derivatives as S-Adenosyl-L-Homocysteine Hydrolase Inhibitors
    Tan, Xiangduan
    Wang, Panfeng
    Nian, Siyun
    Wang, Guoping
    CHEMICAL & PHARMACEUTICAL BULLETIN, 2014, 62 (01) : 112 - 117
  • [10] Recent advances in S-adenosyl-L-homocysteine hydrolase inhibitors and their potential clinical applications
    Yuan, CS
    Saso, Y
    Lazarides, E
    Borchardt, RT
    Robins, MJ
    EXPERT OPINION ON THERAPEUTIC PATENTS, 1999, 9 (09) : 1197 - 1206
12345