Piperazinyl oxime ethers as NK-1 receptor antagonists

被引：2

作者：

van den Hoogenband, A ^{[1
]}

van Maarseveen, JH ^{[1
]}

McCreary, AC ^{[1
]}

Mulder, AT ^{[1
]}

van Scharrenburg, GJM ^{[1
]}

van Stuivenberg, HH ^{[1
]}

Zethof, TJJ ^{[1
]}

Zijta, B ^{[1
]}

Bakker, WII ^{[1
]}

机构：

[1] Solvay Pharmaceut, Res Labs, NL-1381 CP Weesp, Netherlands

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2006年 / 16卷 / 04期

关键词：

neurokinin; synthesis; SAR; oxime ethers;

D O I：

10.1016/j.bmcl.2005.10.077

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The synthesis and structure-activity relations for a new class of centrally active NK-1 receptor antagonists are described. The new compounds are based on piperazine 2 and contain an oxime ether functionality. Several new compounds have high affinity for the NK-1 receptor and show good antagonistic activity in the gerbil foot-tapping assay. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：1045 / 1048

页数：4

共 11 条

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