Porous Crystalsomes via Emulsion Crystallization and Polymer Phase Separation

被引：15

作者：

Staub, Mark C. ^{[1
]}

Kim, Seyong ^{[1
]}

Yu, Shichen ^{[1
]}

Li, Christopher Y. ^{[1
]}

机构：

[1] Drexel Univ, Dept Mat Sci & Engn, Philadelphia, PA 19104 USA

来源：

ACS MACRO LETTERS | 2022年 / 11卷 / 08期

基金：

美国国家科学基金会;

关键词：

Cardiovascular system - Controlled drug delivery - Emulsification - Morphology - Phase separation - Targeted drug delivery;

D O I：

10.1021/acsmacrolett.2c00347

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

Crystalsomes are crystalline capsules that are formed by controlling polymer crystallization to break translational symmetry. While recent studies showed that these crystalline capsules exhibit interesting mechanical properties, thermal behavior, and excellent performance in blood circulation, the closed capsule is undesired for drug delivery applications. We report the formation and characterization of porous crystalsomes where porosity is rendered on the crystalline shells. A miniemulsion is formed using two amphiphilic block copolymers (BCP). The competition between controlled crystallization and phase separation of the BCPs at the emulsion surface leads to multiphase crystalsomes. Subsequently removing one BCP produces porous crystalline capsules.

引用

页码：1022 / 1027

页数：6

共 26 条

[1] Synthesis of Microspheres as Versatile Functional Scaffolds for Materials Science Applications [J].

Barner, Leonie .

ADVANCED MATERIALS, 2009, 21 (24) :2547-2553

[2] Methacrylate-based chromatographic media [J].

Benes, MJ ;

Horák, D ;

Svec, F .

JOURNAL OF SEPARATION SCIENCE, 2005, 28 (15) :1855-1875

[3] Anisotropic ion transport in 2D polymer single crystal-based solid polymer electrolytes [J].

Cheng, Shan ;

Li, Xiaowei ;

Zheng, Yongwei ;

Smith, Derrick M. ;

Li, Christopher Y. .

GIANT, 2020, 2

[4]

Christian DA, 2009, NAT MATER, V8, P843, DOI [10.1038/NMAT2512, 10.1038/nmat2512]

[5] Suspension polymerisation to form polymer beads [J].

Dowding, PJ ;

Vincent, B .

COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, 2000, 161 (02) :259-269

[6] Next-Generation Ultrafiltration Membranes Enabled by Block Polymers [J].

Hampu, Nicholas ;

Werber, Jay R. ;

Chan, Wui Yarn ;

Feinberg, Elizabeth C. ;

Hillmyer, Marc A. .

ACS NANO, 2020, 14 (12) :16446-16471

[7] Well-ordered nanohybrids and nanoporous materials from gyroid block copolymer templates [J].

Hsueh, Han-Yu ;

Yao, Cheng-Thai ;

Ho, Rong-Ming .

CHEMICAL SOCIETY REVIEWS, 2015, 44 (07) :1974-2018

[8] Dispersion polymerization [J].

Kawaguchi, S ;

Ito, K .

POLYMER PARTICLES, 2005, 175 (175) :299-328

[9] Microporous Polyimides with Uniform Pores for Adsorption and Separation of CO2 Gas and Organic Vapors [J].

Li, Guiyang ;

Wang, Zhonggang .

MACROMOLECULES, 2013, 46 (08) :3058-3066

[10] The development of microgels/nanogels for drug delivery applications [J].

Oh, Jung Kwon ;

Drumright, Ray ;

Siegwart, Daniel J. ;

Matyjaszewski, Krzysztof .

PROGRESS IN POLYMER SCIENCE, 2008, 33 (04) :448-477

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