BDNF as a pain modulator

被引：317

作者：

Merighi, Adalberto ^{[1
,2
]}

Salio, Chiara ^{[1
]}

Ghirri, Alessia ^{[3
]}

Lossi, Laura ^{[1
,2
]}

Ferrini, Francesco ^{[1
]}

Betelli, Chiara ^{[3
]}

Bardoni, Rita ^{[3
]}

机构：

[1] Univ Turin, Dipartimento Morfofisiol Vet, Turin, Italy

[2] Ist Nazl Neurosci INN, Turin, Italy

[3] Univ Modena & Reggio Emilia, Dipartimento Sci Biomed, Modena, Italy

来源：

PROGRESS IN NEUROBIOLOGY | 2008年 / 85卷 / 03期

关键词：

BDNF; pain; spinal cord; neuropeptides; glutamate;

D O I：

10.1016/j.pneurobio.2008.04.004

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

At least some neurotrophins may be powerful modulators of synapses, thereby influencing short- and long-term synaptic efficiency. BDNF acts at central synapses in pain pathways both at spinal and supraspinal levels. Neuronal synthesis, subcellular storage/co-storage and release of BDNF at these synapses have been characterized on anatomical and physiological grounds, in parallel with trkB (the high affinity BDNF receptor) distribution. Histological and functional evidence has been provided, mainly from studies on acute slices and intact animals, that BDNF modulates fast excitatory (glutamatergic) and inhibitory (GABAergic/glycinergic) signals, as well as slow peptidergic neurotrasmission in spinal cord. Recent studies have unraveled some of the neuronal circuitries and mechanisms involved, highlighting the key role of synaptic glomeruli in lamina II as the main sites for such a modulation. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：297 / 317

页数：21

共 263 条

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