Cardiac mechanosensitivity and stretch-activated ion channels

被引：21
作者：
Bett, GCL
Sachs, F
机构：
[1] Department of Biophysical Sciences, State University of New York, Buffalo
来源：
TRENDS IN CARDIOVASCULAR MEDICINE | 1997年 / 7卷 / 01期
关键词：
D O I：
10.1016/S1050-1738(96)00119-3
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Mechanosensitivity is a ubiquitous property of cells, and mechanosensitive ion channels (MSCs) are hypothesized to be the transducers. In the heart MSCs are likely to account for changes in beating rate as a function of filling and for initiating stretch-induced arrhythmias (for example, following a myocardial infarction). Pharmacological agents that affect MSCs may provide a new class of antiarrhythmic drugs. (C) 1997, Elsevier Science Inc.
引用
收藏
页码：4 / 8
页数：5
相关论文
共 65 条
[1]   MECHANOELECTRICAL FEEDBACK IN CARDIAC MYOCYTES FROM STRETCH-ACTIVATED ION CHANNELS [J].
AKAY, M ;
CRAELIUS, W .
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING, 1993, 40 (08) :811-816
[2]   PROGNOSIS OF PATIENTS WITH SUSTAINED VENTRICULAR-TACHYCARDIA AND OF SURVIVORS OF CARDIAC-ARREST NOT INDUCIBLE BY PROGRAMMED STIMULATION [J].
ANDRESEN, D ;
STEINBECK, G ;
BRUGGEMANN, T ;
HABERL, R ;
FINK, L ;
SCHRODER, R .
AMERICAN JOURNAL OF CARDIOLOGY, 1992, 70 (15) :1250-1254
[3]  
Bainbridge FA, 1915, J PHYSIOL-LONDON, V50, P65
[4]  
Bett G. C. L., 1996, Biophysical Journal, V70, pA346
[5]   ELECTROPHYSIOLOGICAL EFFECT OF VOLUME LOAD IN ISOLATED CANINE HEARTS [J].
CALKINS, H ;
MAUGHAN, WL ;
KASS, DA ;
SAGAWA, K ;
LEVINE, JH .
AMERICAN JOURNAL OF PHYSIOLOGY, 1989, 256 (06) :H1697-H1706
[6]   Ca2+ uptake in GH(3) cells during hypotonic swelling: The sensory role of stretch-activated ion channels [J].
Chen, Y ;
Simasko, SM ;
Niggel, J ;
Sigurdson, WJ ;
Sachs, F .
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 1996, 270 (06) :C1790-C1798
[7]  
DELUNA AB, 1990, REV PORT CARDIOL, V9, P473
[8]   MECHANICALLY INDUCED ACTION-POTENTIAL CHANGES AND ARRHYTHMIA IN ISOLATED AND INSITU CANINE HEARTS [J].
FRANZ, MR ;
BURKHOFF, D ;
YUE, DT ;
SAGAWA, K .
CARDIOVASCULAR RESEARCH, 1989, 23 (03) :213-223
[9]   ELECTROPHYSIOLOGICAL EFFECTS OF MYOCARDIAL STRETCH AND MECHANICAL DETERMINANTS OF STRETCH-ACTIVATED ARRHYTHMIAS [J].
FRANZ, MR ;
CIMA, R ;
WANG, D ;
PROFITT, D ;
KURZ, R .
CIRCULATION, 1992, 86 (03) :968-978
[10]  
FRANZ MR, 1992, CIRCULATION, V86, P1663
1234567