HPLC-ESIMSn Profiling, Isolation, Structural Elucidation, and Evaluation of the Antioxidant Potential of Phenolics from Paepalanthus geniculatus

被引：33

作者：

do Amaral, Fabiano Pereira ^{[2
]}

Napolitano, Assunta ^{[1
]}

Masullo, Milena ^{[1
]}

dos Santos, Lourdes Campaner ^{[2
]}

Festa, Michela ^{[1
]}

Vilegas, Wagner ^{[2
]}

Pizza, Cosimo ^{[1
]}

Piacente, Sonia ^{[1
]}

机构：

[1] Univ Salerno, Dipartimento Sci Farmaceut & Biomed, I-84084 Fisciano, SA, Italy

[2] Sao Paulo State Univ, UNESP, Dept Organ Chem, Inst Chem, BR-14800900 Sao Paulo, Brazil

来源：

JOURNAL OF NATURAL PRODUCTS | 2012年 / 75卷 / 04期

关键词：

NAPHTHOPYRANONE GLYCOSIDES; ANTIINFLAMMATORY ACTIVITY; ISOCOUMARIN PAEPALANTINE; IN-VIVO; BROMELIOIDES; CONSTITUENTS; DIMER; ERIOCAULACEAE; VELLOZIOIDES; PLANIFOLIUS;

D O I：

10.1021/np200604k

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

The methanol extract of the flowers of Paepalanthus geniculatus Kunth. showed radical-scavenging activity in the TEAC assay. An analytical approach based on HPLC:ESIMSn was applied to obtain the metabolite profile of this extract and led to the rapid identification of 19 polyphenolic compounds comprising flavonoids and naphthopyranones. The new naphthopyranone (10, 16), quercetagetin (1, 5, 7, 13), and galetine derivatives (9, 11, 17, 19), and a flavonol glucoside cyclodimer in the truxillate form (12), were identified. Compounds 2, 6, and 7 showed the highest antioxidant capacity and ability to affect the levels of intracellular ROS in human prostate cancer cells (PC3).

引用

页码：547 / 556

页数：10

共 29 条

[21] Evaluation of the genotoxic potential of the isocoumarin paepalantine in in vivo and in vitro mammalian systems [J].

Tavares, DC ;

Varanda, EA ;

Andrade, FDP ;

Vilegas, W ;

Takahashi, CS .

JOURNAL OF ETHNOPHARMACOLOGY, 1999, 68 (1-3) :115-120

[22] FLAVONOID CONSTITUENTS OF HYMENOXYS SCAPOSA DC (COMPOSITAE) [J].

THOMAS, MB ;

MABRY, TJ .

PHYTOCHEMISTRY, 1968, 7 (05) :787-&

[23]

Varanda EA, 1997, TERATOGEN CARCIN MUT, V17, P85, DOI 10.1002/(SICI)1520-6866(1997)17:2<85::AID-TCM4>3.0.CO

[24]

2-A

[25] Mutagenic and cytotoxic effect of planifolin:: A naphthopyranone dimer isolated from Paepalanthus planifolius [J].

Varanda, EA ;

Varella, SD ;

Rampazo, RA ;

Kitagawa, RR ;

Raddi, MSG ;

Vilegas, W ;

dos Santos, LC .

TOXICOLOGY IN VITRO, 2006, 20 (05) :664-668

[26] Mutagenicity of paepalantine dimer and glycoside derivatives from Paepalanthus bromelioides [J].

Varanda, EA ;

Devienne, KF ;

Raddi, MSG ;

Furuya, EM ;

Vilegas, W .

TOXICOLOGY IN VITRO, 2004, 18 (01) :109-114

[27] ISOCOUMARIN FROM PAEPALANTHUS-BROMELIOIDES [J].

VILEGAS, W ;

ROQUE, NF ;

SALATINO, A ;

GIESBRECHT, AM ;

DAVINO, S .

PHYTOCHEMISTRY, 1990, 29 (07) :2299-2301

[28] Naphthopyranone glycosides from Paepalanthus bromelioides [J].

Vilegas, W ;

Santos, LC ;

Alécio, AC ;

Pizza, C ;

Piacente, S ;

De Pauw, E ;

Sano, PT .

PHYTOCHEMISTRY, 1998, 49 (01) :207-210

[29] Quercetagetin 7-methyl ether glycosides from Paepalanthus vellozioides and Paepalanthus latipes [J].

Vilegas, W ;

Nehme, CJ ;

Dokkeddal, AL ;

Piacente, S ;

Rastrelli, L ;

Pizza, C .

PHYTOCHEMISTRY, 1999, 51 (03) :403-409

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