Hypertrophy of the heart - A new therapeutic target?

被引：713
作者：
Frey, N
Katus, HA
Olson, EN
Hill, JA
机构：
[1] Univ Texas, SW Med Ctr, Dept Internal Med, Div Cardiol, Dallas, TX 75390 USA
[2] Univ Texas, SW Med Ctr, Dept Mol Biol, Dallas, TX 75390 USA
[3] Univ Texas, SW Med Ctr, Donald W Reynolds Cardiovasc Clin Res Ctr, Dallas, TX 75390 USA
[4] Heidelberg Univ, Dept Cardiol Innere Med 3, Heidelberg, Germany
来源：
CIRCULATION | 2004年 / 109卷 / 13期
关键词：
hypertrophy; heart failure; signal transduction;
D O I：
10.1161/01.CIR.0000120390.68287.BB
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Recent studies call into question the necessity of hypertrophic growth of the heart as a "compensatory" response to hemodynamic stress. These findings, coupled with recent progress in dissecting the molecular bases of hypertrophy, raise the prospect of suppressing hypertrophy without provoking circulatory insufficiency. In this article, we focus on signaling pathways that hold promise as potential targets for therapeutic intervention. We also summarize observations from animal models and clinical trials that suggest benefit from an antihypertrophic strategy.
引用
收藏
页码：1580 / 1589
页数：10
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