Effect of nano-HA content on the mechanical properties, degradation and biocompatible behavior of Mg-Zn/HA composite prepared by spark plasma sintering

被引：72

作者：

Cui, Zeqin ^{[1
,2
]}

Li, Weijian ^{[1
,2
]}

Cheng, Linxin ^{[1
]}

Gong, Dianqing ^{[1
,2
]}

Cheng, Weili ^{[1
,2
]}

Wang, Wenxian ^{[1
,2
]}

机构：

[1] Taiyuan Univ Technol, Coll Mat Sci & Engn, Taiyuan 030024, Shanxi, Peoples R China

[2] Shanxi Key Lab Adv Magnesium Based Mat, Taiyuan 030024, Shanxi, Peoples R China

来源：

MATERIALS CHARACTERIZATION | 2019年 / 151卷

基金：

中国国家自然科学基金;

关键词：

Biodegradable Mg-based composite; Spark plasma sintering (SPS); Corrosion behavior; Cytotoxicity evaluation; IN-VITRO DEGRADATION; CORROSION BEHAVIOR; MAGNESIUM ALLOYS; VOLUME FRACTION; MICROSTRUCTURE; ZN; HYDROXYAPATITE; FABRICATION; SCAFFOLDS; ZINC;

D O I：

10.1016/j.matchar.2019.03.048

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

Recently, Mg-Zn alloy had been investigated as biodegradable material for fabricating orthopedic implants. In this paper, nano-hydroxyapatite (nano-HA) [Ca-10(FO4)(6)(OH)(2)] was uniformly distributed on the surface of magnesium particles by ball milling process, and then the composite of Mg-5.5Zn/HA was successfully fabricated by spark plasma sintering (SPS). Effect of the nano-HA content on the compressive strength and the bioactivity in vitro (corrosion behavior, cytotoxicity) of the composite was analyzed. Results indicated that with the increasing of the nano-HA content (from 0 to 10 wt%), the compressive yield strength is improved remarkably. Comparing with Mg-5.5Zn alloy, of the nano-HA (10 wt%) can improve the compressive yield strength by 43% and bending strength by 14%. Furthermore, the in-vitro immersion tests revealed the positive and negative effects of nano-HA content on the corrosion behavior of Mg-5.5Zn/HA composite. The nano-HA can improve the degradation resistance of the Mg-5.5Zn matrix. Addition of 10 wt% HA can decrease the corrosion rate by 49%. Furthermore, the composite exhibits acceptable cytotoxicity to L-929 cells, and impressive potential to be used as an orthopedic implant material.

引用

页码：620 / 631

页数：12

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