Effect of nano-HA content on the mechanical properties, degradation and biocompatible behavior of Mg-Zn/HA composite prepared by spark plasma sintering

被引：72
作者：
Cui, Zeqin [1 ,2 ]
Li, Weijian [1 ,2 ]
Cheng, Linxin [1 ]
Gong, Dianqing [1 ,2 ]
Cheng, Weili [1 ,2 ]
Wang, Wenxian [1 ,2 ]
机构：
[1] Taiyuan Univ Technol, Coll Mat Sci & Engn, Taiyuan 030024, Shanxi, Peoples R China
[2] Shanxi Key Lab Adv Magnesium Based Mat, Taiyuan 030024, Shanxi, Peoples R China
来源：
MATERIALS CHARACTERIZATION | 2019年 / 151卷
基金：
中国国家自然科学基金;
关键词：
Biodegradable Mg-based composite; Spark plasma sintering (SPS); Corrosion behavior; Cytotoxicity evaluation; IN-VITRO DEGRADATION; CORROSION BEHAVIOR; MAGNESIUM ALLOYS; VOLUME FRACTION; MICROSTRUCTURE; ZN; HYDROXYAPATITE; FABRICATION; SCAFFOLDS; ZINC;
D O I：
10.1016/j.matchar.2019.03.048
中图分类号：
T [工业技术];
学科分类号：
08 ;
摘要：
Recently, Mg-Zn alloy had been investigated as biodegradable material for fabricating orthopedic implants. In this paper, nano-hydroxyapatite (nano-HA) [Ca-10(FO4)(6)(OH)(2)] was uniformly distributed on the surface of magnesium particles by ball milling process, and then the composite of Mg-5.5Zn/HA was successfully fabricated by spark plasma sintering (SPS). Effect of the nano-HA content on the compressive strength and the bioactivity in vitro (corrosion behavior, cytotoxicity) of the composite was analyzed. Results indicated that with the increasing of the nano-HA content (from 0 to 10 wt%), the compressive yield strength is improved remarkably. Comparing with Mg-5.5Zn alloy, of the nano-HA (10 wt%) can improve the compressive yield strength by 43% and bending strength by 14%. Furthermore, the in-vitro immersion tests revealed the positive and negative effects of nano-HA content on the corrosion behavior of Mg-5.5Zn/HA composite. The nano-HA can improve the degradation resistance of the Mg-5.5Zn matrix. Addition of 10 wt% HA can decrease the corrosion rate by 49%. Furthermore, the composite exhibits acceptable cytotoxicity to L-929 cells, and impressive potential to be used as an orthopedic implant material.
引用
收藏
页码：620 / 631
页数：12
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