The effect of verbascoside on cyclic 3',5'-adenosine monophosphate levels in isolated rat heart

被引:29
作者
Pennacchio, M
Alexander, E
Syah, YM
Ghisalberti, EL
机构
[1] CURTIN UNIV TECHNOL,SCH ENVIRONM BIOL,PERTH,WA 6001,AUSTRALIA
[2] UNIV WESTERN AUSTRALIA,DEPT CHEM,NEDLANDS,WA 6907,AUSTRALIA
关键词
verbascoside; cyclic adenosine monophosphate; Langendorff heart preparation; Eremophila alternifolia;
D O I
10.1016/0014-2999(96)00153-7
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The effects mediated by the naturally occurring phenylethanoid glycoside verbascoside (1 mM) in isolated rat hearts (significant increases in heart rate (42%), contractile force (13%) and coronary perfusion rate (113%)) all coincided with a marked increase in intracellular levels of cyclic-3',5'-adenosine monophosphate (1733% increase).
引用
收藏
页码:169 / 171
页数:3
相关论文
共 12 条
[1]  
ANDARY C, 1980, FARMACO-ED SCI, V35, P3
[2]   SIMPLE AND SENSITIVE SATURATION ASSAY METHOD FOR MEASUREMENT OF ADENOSINE 3'-5'-CYCLIC MONOPHOSPHATE [J].
BROWN, BL ;
ALBANO, JDM ;
EKINS, RP ;
SGHERZI, AM ;
TAMPION, W .
BIOCHEMICAL JOURNAL, 1971, 121 (03) :561-+
[3]   THE ETHNOPHARMACOLOGY AND PHYTOCHEMISTRY OF EREMOPHILA SPECIES (MYOPORACEAE) [J].
GHISALBERTI, EL .
JOURNAL OF ETHNOPHARMACOLOGY, 1994, 44 (01) :1-9
[4]  
JIMENEZ C, 1994, NAT PROD REP, V12, P591
[5]   EFFECTS OF CAFFEOYLGLYCOSIDES ON ARACHIDONATE METABOLISM IN LEUKOCYTES [J].
KIMURA, Y ;
OKUDA, H ;
NISHIBE, S ;
ARICHI, S .
PLANTA MEDICA, 1987, (02) :148-153
[6]  
KITAGAWA S, 1984, CHEM PHARM BULL, V32, P1209
[7]   THE GENESIS OF ARRHYTHMIAS DURING MYOCARDIAL ISCHEMIA - DISSOCIATION BETWEEN CHANGES IN CYCLIC ADENOSINE-MONOPHOSPHATE AND ELECTRICAL INSTABILITY IN THE RAT [J].
MANNING, AS ;
KINOSHITA, K ;
BUSCHMANS, E ;
COLTART, DJ ;
HEARSE, DJ .
CIRCULATION RESEARCH, 1985, 57 (05) :668-675
[8]  
METZGER H, 1981, ARZNEIMITTEL-FORSCH, V31-2, P1248
[9]  
MONCADA S, 1977, LANCET, V1, P18
[10]   PATHOPHYSIOLOGY OF CHRONIC HEART-FAILURE [J].
PACKER, M .
LANCET, 1992, 340 (8811) :88-92