The effect of verbascoside on cyclic 3',5'-adenosine monophosphate levels in isolated rat heart

被引：30

作者：

Pennacchio, M

Alexander, E

Syah, YM

Ghisalberti, EL

机构：

[1] CURTIN UNIV TECHNOL,SCH ENVIRONM BIOL,PERTH,WA 6001,AUSTRALIA

[2] UNIV WESTERN AUSTRALIA,DEPT CHEM,NEDLANDS,WA 6907,AUSTRALIA

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1996年 / 305卷 / 1-3期

关键词：

verbascoside; cyclic adenosine monophosphate; Langendorff heart preparation; Eremophila alternifolia;

D O I：

10.1016/0014-2999(96)00153-7

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The effects mediated by the naturally occurring phenylethanoid glycoside verbascoside (1 mM) in isolated rat hearts (significant increases in heart rate (42%), contractile force (13%) and coronary perfusion rate (113%)) all coincided with a marked increase in intracellular levels of cyclic-3',5'-adenosine monophosphate (1733% increase).

引用

页码：169 / 171

页数：3

共 12 条

[1]

ANDARY C, 1980, FARMACO-ED SCI, V35, P3

[2] SIMPLE AND SENSITIVE SATURATION ASSAY METHOD FOR MEASUREMENT OF ADENOSINE 3'-5'-CYCLIC MONOPHOSPHATE [J].