The crystal structure of the eukaryotic 40S ribosomal subunit in complex with eIF1 and eIF1A

被引：67

作者：

Weisser, Melanie ^{[1
]}

Voigts-Hoffmann, Felix ^{[1
]}

Rabl, Julius ^{[1
]}

Leibundgut, Marc ^{[1
]}

Ban, Nenad ^{[1
]}

机构：

[1] ETH, Inst Mol Biol & Biophys, Swiss Fed Inst Technol, CH-8093 Zurich, Switzerland

来源：

NATURE STRUCTURAL & MOLECULAR BIOLOGY | 2013年 / 20卷 / 08期

基金：

瑞士国家科学基金会;

关键词：

SEQUENCE ALIGNMENT EDITOR; START CODON SELECTION; INITIATION-FACTORS; 1A; TRANSLATION INITIATION; IN-VIVO; BINDING; QUALITY; RNA; RECOGNITION; SOFTWARE;

D O I：

10.1038/nsmb.2622

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Eukaryotic translation initiation factors (eIFs) 1A and 1 are central players in the complex process of start-codon recognition. To improve mechanistic understanding of this process, we determined the crystal structure of the 40S ribosomal subunit in complex with eIF1A and eIF1 from Tetrahymena thermophila at a resolution of 3.7 angstrom. It reveals the positions of the two factors on the 40S and the conformational changes that accompany their binding.

引用

页码：1015 / +

页数：4

共 50 条

[41] Cyst stem cell lineage eIF5 non-autonomously prevents testicular germ cell tumor formation via eIF1A/eIF2γ-mediated pre-initiation complex [J].

Li, Zhiran ;

Wu, Yunhao ;

Fu, Yangbo ;

Chen, Xia ;

Zhao, Xi ;

Wu, Xiaolong ;

Lu, Yajuan ;

He, Hui ;

Shen, Cong ;

Zheng, Bo ;

Yu, Jun ;

Sun, Fei .

STEM CELL RESEARCH & THERAPY, 2022, 13 (01)

[42] Human AATF/Che-1 forms a nucleolar protein complex with NGDN and NOL10 required for 40S ribosomal subunit synthesis [J].

Bammert, Lukas ;

Jonas, Stefanie ;

Ungricht, Rosemarie ;

Kutay, Ulrike .

NUCLEIC ACIDS RESEARCH, 2016, 44 (20) :9803-9820

[43] Hepatitis-C-virus-like internal ribosome entry sites displace eIF3 to gain access to the 40S subunit [J].

Hashem, Yaser ;

des Georges, Amedee ;

Dhote, Vidya ;

Langlois, Robert ;

Liao, Hstau Y. ;

Grassucci, Robert A. ;

Pestova, Tatyana V. ;

Hellen, Christopher U. T. ;

Frank, Joachim .

NATURE, 2013, 503 (7477) :539-+

[44] Functional Characterization of the Role of the N-terminal Domain of the c/Nip1 Subunit of Eukaryotic Initiation Factor 3 (eIF3) in AUG Recognition [J].

Karaskova, Martina ;

Gunisova, Stanislava ;

Herrmannova, Anna ;

Wagner, Susan ;

Munzarova, Vanda ;

Valasek, Leos Shivaya .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2012, 287 (34) :28420-28434

[45] The cholangiocyte marker, BD. 1, forms a stable complex with CLIP170 and shares an identity with eIF3a, a multifunctional subunit of the eIF3 initiation complex [J].

Mills, David R. ;

Rozich, Rebecca A. ;

Flanagan, Donna L. ;

Brilliant, Kate E. ;

Yang, DongQin ;

Hixson, Douglas C. .

EXPERIMENTAL AND MOLECULAR PATHOLOGY, 2012, 93 (02) :250-260

[46] A bacterial homolog YciH of eukaryotic translation initiation factor eIF1 regulates stress-related gene expression and is unlikely to be involved in translation initiation fidelity [J].

Osterman, Ilya A. ;

Evfratov, Sergey A. ;

Dzama, Margarita M. ;

Pletnev, Philipp I. ;

Kovalchuk, Sergey I. ;

Butenko, Ivan O. ;

Pobeguts, Olga V. ;

Golovina, Anna Ya ;

Govorun, Vadim M. ;

Bogdanov, Alexey A. ;

Sergiev, Petr V. ;

Dontsova, Olga A. .

RNA BIOLOGY, 2015, 12 (09) :966-971

[47] The human translation initiation multi-factor complex promotes methionyl-tRNAi binding to the 40S ribosomal subunit [J].

Sokabe, Masaaki ;

Fraser, Christopher S. ;

Hershey, John W. B. .

NUCLEIC ACIDS RESEARCH, 2012, 40 (02) :905-913

[48] Arrangements of nucleotides flanking the start codon in the IRES of the hepatitis C virus in the IRES binary complex with the human 40S ribosomal subunit [J].

Babaylova, Elena S. ;

Graifer, Dmitri M. ;

Malygin, Alexey A. ;

Karpova, Galina G. .

BIOCHIMIE, 2018, 148 :72-79

[49] Modeling of Structure and Dynamics of Eukaryotic Ribosomal Termination Complex of eRF1-mRNA-tRNA [J].

Vorobjev, Y. N. .

JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS, 2009, 26 (06) :822-824

[50] Archaeal Translation Initiation Factor aIF2 Can Substitute for Eukaryotic eIF2 in Ribosomal Scanning during Mammalian 48S Complex Formation [J].

Dmitriev, Sergey E. ;

Stolboushkina, Elena A. ;

Terenin, Ilya M. ;

Andreev, Dmitri E. ;

Garber, Maria B. ;

Shatsky, Ivan N. .

JOURNAL OF MOLECULAR BIOLOGY, 2011, 413 (01) :106-114

← 1 2 3 4 5 →