Coumarins: Facile and Expeditious Synthesis via Keggin-Type Heteropolycompounds under Solvent-Free Condition

被引：7
作者：
Rafiee, Ezzat [1 ,2 ]
Fakhri, Akram [1 ]
Joshaghani, Mohammad [1 ,2 ]
机构：
[1] Razi Univ, Fac Chem, Kermanshah 67149, Iran
[2] Kermanshah Oil Refining Co, Kermanshah, Iran
来源：
JOURNAL OF HETEROCYCLIC CHEMISTRY | 2013年 / 50卷 / 05期
关键词：
ACIDIC IONIC LIQUIDS; PECHMANN REACTION; REUSABLE CATALYST; DERIVATIVES; EFFICIENT; CONDENSATION; GREEN;
D O I：
10.1002/jhet.621
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Different Keggin-type heteropolycompounds were used in Pechmann reaction to obtain biologically active coumarins. Effect of solvent, catalyst loading, and molar ratios of substrates was studied to introduce the best reaction condition. The optimized reaction condition was extended to Pechmann reaction of methylacetoacetate with various monohydric and polyhydric phenols. This rapid procedure afforded structurally diverse coumarins with high to excellent yields. Short reaction times, simple work-up, and mild reaction conditions were advantages of this method. The optimized catalysts were reusable for four runs.
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收藏
页码：1121 / 1128
页数：8
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