SYNTHESIS OF NOVEL 1-ALKYL-1,2-DIHYDRO-2-IMINO-4-QUINAZOLINAMINES BY TANDEM REACTION OF THE THREE COMPONENTS

被引：1

作者：

Guo, Zhen ^{[1
]}

Yin, Ping ^{[1
]}

He, Ling ^{[1
]}

Qi, Qing Rong ^{[1
]}

机构：

[1] Sichuan Univ, West China Sch Pharm, Key Lab Drug Targeting & Drug Delivery Syst, Dept Med Chem,Minist Educ, Chengdu 610041, Sichuan, Peoples R China

来源：

HETEROCYCLES | 2013年 / 87卷 / 07期

基金：

美国国家科学基金会;

关键词：

Quinazoline; Ullmann Coupling Reaction; Ligand-Free Reaction; Amine; GROWTH-FACTOR RECEPTOR; TYROSINE KINASE INHIBITORS; COUPLING REACTIONS; 4(3H)-QUINAZOLINONE DERIVATIVES; QUINAZOLINE DERIVATIVES; ARYL IODIDES; EFFICIENT; AMINATION; CHEMISTRY; ALKALOIDS;

D O I：

10.3987/COM-13-12711

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel and efficient synthesis of quinazoline derivatives involving copper-catalyzed Ullmann-type coupling reaction was developed. These reactions were performed under mild conditions without the addition of a ligand. The coupling reaction and the subsequent cyclization reaction in series gave rise to the formation of intermolecular C-N bond and intramolecular C-N bond and synthesized novel N,N'-disubstituted 1,2-dihydro-2-imino-4-quinazolinamines in moderate to high yields simultaneously.

引用

页码：1493 / +

页数：14

共 44 条

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