Contribution of SDF-1α/CXCR4 Signaling to Brain Development and Glioma Progression

被引：31

作者：

Jiang, Zheng ^{[1
]}

Zhou, Wei ^{[2
]}

Guan, Shanghui ^{[2
]}

Wang, Jianbo ^{[2
]}

Liang, Yemin ^{[2
]}

机构：

[1] Shandong Univ, Qilu Hosp, Dept Neurosurg, Jinan 250012, Shandong, Peoples R China

[2] Shandong Univ, Qilu Hosp, Dept Radiotherapy, Ctr Canc, Jinan 250012, Shandong, Peoples R China

来源：

NEUROSIGNALS | 2013年 / 21卷 / 3-4期

基金：

中国国家自然科学基金;

关键词：

Chemokines; Cancer; Brain; Neuropathology; CHEMOKINE RECEPTOR CXCR4; CELL-DERIVED FACTOR-1-ALPHA; MICROVASCULAR ENDOTHELIAL-CELLS; CENTRAL-NERVOUS-SYSTEM; CAJAL-RETZIUS CELLS; GIANT DEPOLARIZING POTENTIALS; DIPEPTIDYL PEPTIDASE-IV; HIV-1 CORECEPTOR CXCR4; C MOTIF LIGAND-12; ADULT-RAT BRAIN;

D O I：

10.1159/000339091

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The SDF-1 alpha/CXCR4 signaling maintains central nervous system homeostasis through the interaction with the neurotransmitter and neuropeptide systems, the neuroendocrine systems. Recently, the SDF-1 alpha/CXCR4 signaling has been reported to present nonrandom distribution in brain development and glioma progression, which exerts differential regulations on the assembly, differentiation, and function of neural precursors, neurons, glial cells, as well as glioma cells. In the present review, we highlight current knowledge about multiple molecular signaling pathways associated with the SDF-1 alpha/CXCR4 signaling in glioma. Not only is the expression of CXCR4 a key determinant of glioma progression, but SDF-1 alpha is essential for site-specific invasive or metastatic processes. SDF-1 alpha is the switch of the SDF-1 alpha/CXCR4 signaling from the endocrine loop to the autocrine and/or local paracrine loop in glioma progression and brain development. Studies of SDF-1 alpha/CXCR4 signaling in the field of brain development may provide valuable tactics for glioma treatment. Copyright (c) 2012 S. Karger AG, Basel

引用

页码：240 / 258

页数：19

共 200 条

[1] Are chemokines the third major system in the brain? [J].

Adler, MW ;

Rogers, TJ .

JOURNAL OF LEUKOCYTE BIOLOGY, 2005, 78 (06) :1204-1209

[2] Tumor stromal-derived factor-1 recruits vascular progenitors to mitotic neovasculature, where microenvironment influences their differentiated phenotypes [J].

Aghi, Manish ;

Cohen, Kenneth S. ;

Klein, Rachael J. ;

Scadden, David T. ;

Chioccra, E. Antonio .

CANCER RESEARCH, 2006, 66 (18) :9054-9064

[3] Brain-derived neurotrophic factor modulates expression of chemokine receptors in the brain [J].

Ahmed, Farid ;

Tessarollo, Lino ;

Thiele, Carol ;

Mocchetti, Italo .

BRAIN RESEARCH, 2008, 1227 :1-11

[4] HIV-1 envelope glycoprotein 120 induces cyclooxygenase-2 expression in astrocytoma cells through a nuclear factor-κB-dependent mechanism [J].

Alcarez, Susana ;

Serramia, M. Jesus ;

Fresno, Manuel ;

Munoz-Fernandez, M. Angeles .

NEUROMOLECULAR MEDICINE, 2007, 9 (02) :179-193

[5] Nuclear factor-κB activation regulates cyclooxygenase-2 induction in human astrocytes in response to CXCL12: role in neuronal toxicity [J].

Alvarez, Susana ;

Blanco, Almudena ;

Fresno, Manuel ;

Angeles Munoz-Fernandez, Ma .

JOURNAL OF NEUROCHEMISTRY, 2010, 113 (03) :772-783

[6] Distinct origins of neocortical projection neurons and interneurons in vivo [J].

Anderson, SA ;

Kaznowski, CE ;

Horn, C ;

Rubenstein, JLR ;

McConnell, SK .

CEREBRAL CORTEX, 2002, 12 (07) :702-709

[7] Control of axon elongation via an SDF-1α/Rho/mDia pathway in cultured cerebellar granule neurons [J].

Arakawa, Y ;

Bito, H ;

Furuyashiki, T ;

Tsuji, T ;

Takemoto-Kimura, S ;

Kimura, K ;

Nozaki, K ;

Hashimoto, N ;

Narumiya, S .

JOURNAL OF CELL BIOLOGY, 2003, 161 (02) :381-391

[8]

Bagri A, 2002, DEVELOPMENT, V129, P4249

[9] Stromal cell-derived factor-1α induces astrocyte proliferation through the activation of extracellular signal-regulated kinases 1/2 pathway [J].

Bajetto, A ;

Barbero, S ;

Bonavia, R ;

Piccioli, P ;

Pirani, P ;

Florio, T ;

Schettini, G .

JOURNAL OF NEUROCHEMISTRY, 2001, 77 (05) :1226-1236

[10] Expression of CXC chemokine receptors 1-5 and their ligands in human glioma tissues: Role of CXCR4 and SDF1 in glioma cell proliferation and migration [J].

Bajetto, Adriana ;

Barbieri, Federica ;

Dorcaratto, Alessandra ;

Barbero, Simone ;

Daga, Antonio ;

Porcile, Carola ;

Ravetti, Jean Louis ;

Zona, Gianluigi ;

Spaziante, Renato ;

Corte, Giorgio ;

Schettini, Gennaro ;

Florio, Tullio .

NEUROCHEMISTRY INTERNATIONAL, 2006, 49 (05) :423-432

← 1 2 3 4 5 6 7 8 9 10 →