Physical Properties and Erosion Behavior of Poly(trimethylene carbonate-co-ε-caprolactone) Networks

被引：11

作者：

Bat, Erhan ^{[1
]}

van Kooten, Theo G. ^{[2
]}

Harmsen, Martin C. ^{[3
]}

Plantinga, Josee A. ^{[1
]}

van Luyn, Marja J. A. ^{[3
]}

Feijen, Jan ^{[1
]}

Grijpma, Dirk W. ^{[1
,2
,4
]}

机构：

[1] Univ Twente, Dept Polymer Chem & Biomat, MIRA Inst Biomed Technol & Tech Med, Fac Sci & Technol, NL-7500 AE Enschede, Netherlands

[2] Univ Groningen, Univ Med Ctr Groningen, Dept Biomed Engn, NL-9713 AV Groningen, Netherlands

[3] Univ Groningen, Univ Med Ctr Groningen, Dept Pathol & Med Biol, NL-9713 GZ Groningen, Netherlands

[4] Univ Twente, Dept Biomat Sci & Technol, MIRA Inst Biomed Technol & Tech Med, Fac Sci & Technol, NL-7500 AE Enschede, Netherlands

来源：

MACROMOLECULAR BIOSCIENCE | 2013年 / 13卷 / 05期

关键词：

crosslinking; degradation; poly(epsilon-caprolactone); poly(trimethylene carbonate); surface erosion; IN-VIVO BEHAVIOR; EPSILON-CAPROLACTONE; TRIMETHYLENE CARBONATE; 1,3-TRIMETHYLENE CARBONATE; ENZYMATIC DEGRADATION; MECHANICAL-PROPERTIES; ALIPHATIC POLYESTERS; TISSUE-RESPONSE; CROSS-LINKING; PART;

D O I：

10.1002/mabi.201200373

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Form-stable resorbable networks are prepared by gamma irradiating trimethylene carbonate (TMC)- and epsilon-caprolactone (CL)-based (co)polymer films. To evaluate their suitability for biomedical applications, their physical properties and erosion behavior are investigated. Homopolymer and copolymer networks that are amorphous at room temperature are flexible and rubbery with elastic moduli ranging from 1.8 +/- 0.3 to 5.2 +/- 0.4MPa and permanent set values as low as 0.9% strain. The elastic moduli of the semicrystalline networks are higher and range from 61 +/- 3 to 484 +/- 34MPa. The erosion behavior of (co)polymer networks is investigated in vitro using macrophage cultures, and in vivo by subcutaneous implantation in rats. In macrophage cultures, as well as upon implantation, a surface erosion process is observed for the amorphous (co)polymer networks, while an abrupt decrease in the rate and a change in the nature of the erosion process are observed with increasing crystallinity. These resorbable and form-stable networks with tuneable properties may find application in a broad range of biomedical applications.

引用

页码：573 / 583

页数：11

共 43 条

[1] INFLUENCE OF MOLECULAR-STRUCTURE ON THE DEGRADATION MECHANISM OF DEGRADABLE POLYMERS - IN-VITRO DEGRADATION OF POLY(TRIMETHYLENE CARBONATE), POLY(TRIMETHYLENE CARBONATE-CO-CAPROLACTONE), AND POLY(ADIPIC ANHYDRIDE) [J].